Process for the preparation of a taxane derivative

Details Process for the preparation of a taxane derivative Process for the preparation of a taxane derivative

2007-06-19

2007-06-19

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S297000

Reexamination Certificate

active

11432866

ABSTRACT:
The invention relates to an improved process for the synthesis of 13-(N-Boc-β-isobutylserinyl)-14-β-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarbonate and the 7-hydroxy group is protected with a trichloroacetyl group.

REFERENCES:
patent: 6737534 (2004-05-01), Pontiroli et al.
patent: 6906101 (2005-06-01), Bombardelli et al.
patent: WO 01/02407 (2001-01-01), None

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