Oligonucleotide therapeutic agent and methods of making same

Details Oligonucleotide therapeutic agent and methods of making same Oligonucleotide therapeutic agent and methods of making same

2007-10-23

2007-10-23

Martinell, James (Department: 1634)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120

Reexamination Certificate

active

08078768

ABSTRACT:
For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a biological component, such as a protein, of the organism. The oligonucleotide has about fourteen bases or more, such as twenty-three bases, and can be a deoxyribo-nucleotide. The oligonucleotide sequence can be derived from the organism's ribonucleic or deoxyribonucleic acid that codes for a vital protein, and can be synthesized in bulk either chemically or by insertion into a plasmid.

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