Size-exclusion-based extraction of affinity ligands and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Details

C210S198200, C210S635000, C210S650000, C210S656000, C530S414000, C530S417000, C435S007100, C435S007930

Reexamination Certificate

active

09920435

ABSTRACT:
The invention encompasses an improved, rapid, size-exclusive method for screening for small molecular weight ligands that bind specifically to a protein target, using size-exclusion separation, ultrafiltration, and mass spectrometry.

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Zhao, Y. et al., “Screening Solution-Phase Combinatorial Libraries Using Pulsed Ultrafiltration/Electrospray Mass Spectrometry”, J. Med. Chem. 40:4006-4012 (1997).

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