Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-02-13
2007-02-13
Ewoldt, G. R. (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007920, C424S137100
Reexamination Certificate
active
10374318
ABSTRACT:
The present invention provides a method of predicting the probability of a successful pregnancy, either a naturally achieved pregnancy or a pregnancy resulting from an assisted reproductive technology, based on the level of L-selectin ligand expressed by uterine epithelial cells and/or the level of L-selectin expressed by an embryo in vitro. The invention further provides methods of inhibiting cell adhesion between a trophoblast and a uterine epithelial cell. Methods of inhibiting cell adhesion between a trophoblast and a uterine epithelial cell are useful to inhibit pregnancy. The invention further provides methods of assessing in vitro embryo quality. The invention further provides methods of predicting the probability of continued success of a pregnancy during the first 16 weeks of gestation.
REFERENCES:
patent: 5279941 (1994-01-01), Lessey
patent: 6169071 (2001-01-01), Blaschuk et al.
patent: 6277824 (2001-08-01), Doherty et al.
patent: 6309843 (2001-10-01), Timms
patent: 6326352 (2001-12-01), Blaschuk et al.
Spencer et al., “identification and characterization of glycosylation-dependent cell adhesion molecule 1-like protein expression in the ovine uterus,” 1999, Biology of Reproduction, 60:241-250.
Hey et at., “Sialyl-Lewis x and sialyl-Lewis a are associated with MUC1 in human endothelium,” 1996, Gylcoconjugate Journal, 13:769-779.
Holmes et al., “Preparation of cells and reagents for flow cytometry,” in Current Protocols in Immunology, 2001, John Wiley & Sons, 5.3.1-5.3.24.
Frenette et al., Thromb Haemost (1997) 78:60-64.
Whyte et al., Cell Biol Int (1994) 18:759-766.
Norwitz et al. (2001)N. Engl. J. Med.345:1400-1408.
Bertozzi and Kiessling (2001)Science291:2357-64.
Rosen (1999)Am J Pathol155:1013-20.
Alon et al. (1997)J Cell Biol138:1169-80.
Alon et al. (1998)Proc Natl Acad Sci U S A95:11631-6.
Gunn et al. (1998)Proc Natl Acad Sci U S A95:258-63.
Carson et al. (2000)Dev Biol223:217-37.
Norwitz et al. (2001)N Engl J Med345:1400-1408.
Damsky and Fisher (1998)Curr Opin Cell Biol10:660-6.
Ilic et al. (2001)Am J Pathol159:93-108.
Drake et al. (2001)J Exp Med193:1199-212.
Guleria and Pollard (2000)Nat Med6:589-93.
Sutherland et al. (1993)Development119:1175-1186.
Fisher Susan J.
Genbacev-Krtolica Olga
McMaster Michael T.
Prakobphol Akraporn
Borden Paula A.
Bozicevic Field & Francis LLP
Ewoldt G. R.
Szperka Michael
The Regents of the University of California
LandOfFree
Method of determining endometrial receptivity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of determining endometrial receptivity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of determining endometrial receptivity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3825666