Cyclopentylamine and cyclohexylamine derivatives as...

Details Cyclopentylamine and cyclohexylamine derivatives as... Cyclopentylamine and cyclohexylamine derivatives as...

2007-10-02

2007-10-02

Richter, Johann (Department: 1609)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S508000, C514S712000, C514S716000, C514S719000, C514S724000, C564S453000, C564S501000, C548S400000, C546S184000

Reexamination Certificate

active

11183700

ABSTRACT:
The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compoundsare useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

REFERENCES:
patent: 6136824 (2000-10-01), MacLeod et al.
patent: WO 2004/005255 (2004-01-01), None
patent: WO 2004/005256 (2004-01-01), None
Kramer, Mark S., et al., “Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors”,Science, 281 (1998) 1640-1645.
Maubach, Karen A., et al., “Novel Strategies for Pharmacotherapy of Depression”,Current Opinion in Chemical Biology, 3 (1999) 481-488.
Rosen, Terry J., et al., “Synthesis and Structure-Activity Relationships of CP-122,721, A Second-Generation NK-1 Receptor Antagonist”, ,Bioorganic&Medicinal Chemistry Letters, 8 (1998) 281-284.
Ryckmans, Thomas, et al., “First Dual NK1Antagonists-Serotonin Reuptake Inhibitors: Synthesis and SAR of a New Class of Potential Antidepressants”,Bioorganic&Medicinal Chemistry Letters, 12 (2002) 261-264.

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