Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-01-09
2007-01-09
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S306100, C435S006120
Reexamination Certificate
active
11035627
ABSTRACT:
Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.
REFERENCES:
patent: 4397851 (1983-08-01), Engelhart et al.
patent: 5958950 (1999-09-01), Padia et al.
patent: 6613787 (2003-09-01), Wilson et al.
patent: 6867227 (2005-03-01), Wilson et al.
patent: 2003/0199521 (2003-10-01), Dykstra
patent: WO01/46175 (2001-06-01), None
Hopkins, et al. “Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis Carinii Agents” J. Med. Chem. 1998, 41, 3872-3878.
European Office Action for corresponding European Appl. No. 00989364.5 dated Apr. 4, 2005.
Australian Search Report for corresponding Austalian application No. 25874/01 dated Jan. 25, 2005.
Memo for a Mexican Office Action for corresponding Mexican Appl. No. PA/a/2002/005937.
Boykin David W.
Tidwell Richard R.
Wilson W. David
Georgia State University Research Foundation, Inc.
Grazier Nyeemah
Jenkins Wilson Taylor & Hunt, P.A.
McKane Joseph K.
The University of North Carolina at Chapel Hill
LandOfFree
Compounds that exhibit specific molecular recognition of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds that exhibit specific molecular recognition of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds that exhibit specific molecular recognition of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3823176