Production method of O-substituted tyrosine compound

Details Production method of O-substituted tyrosine compound Production method of O-substituted tyrosine compound

2007-05-15

2007-05-15

Page, Thurman K. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

10937345

ABSTRACT:
The present invention relates to a method of producing a compound represented by the formula [I] or a salt thereof, which comprises reacting a compound represented by the formula [II] or a salt thereof with a compound represented by the formula [III] or a salt thereof, in the presence of a base, in alcohol, and provides a production method of an O-substituted tyrosine compound, which is superior in productivity, versatility and safety, and economically and industrially useful:wherein each symbol is as defined in the specification.

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patent: WO0224625 (2002-03-01), None
patent: WO 0224625 (2002-03-01), None
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Ian Lewis, et al., “A Novel Somatostatin Mimic with Broad Somatotropin Release Inhibitory Factor Receptor Binding and Superior Therapeutic Potential”, Journal of Medicinal Chemistry, vol. 46, No. 12, 2003, pp. 2334-2344.
Christian Wolf, et al., “Enantioselective alkylation of aldehydes promoted by (S)-tyrosine-derived β-amino alcohols”, Tetrahedron: Asymmetry, vol. 13, No. 16, 2002, pp. 1733-1741.
Shiroh Futaki, et al., “Sulphur Trioxide/Thiol: A Novel System for the Reduction of Methionine Supphoxide”, Journal of Chemical Society Parkin Transaction, vol. 3, 1990, pp. 653-658.

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