Chemical compounds

Details Chemical compounds Chemical compounds

1982-06-09

1985-07-02

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546333, 548569, 260239B, 260239BA, 564340, 564341, 564346, 564353, 564354, C07D21106, C07D29510

Patent

active

045269734

ABSTRACT:
Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones of the general formula ##STR1## are potent histamine H.sub.2 -antagonists useful in the treatment of peptic ulcers. A preferred compound, 1-amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione, is prepared by treating an intermediate, 1-methoxy-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dion e, with ammonia.

REFERENCES:
patent: 4062863 (1977-12-01), Ganellin et al.
patent: 4233302 (1980-11-01), Martin-Smith et al.
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4318913 (1982-03-01), Clitherow et al.
patent: 4323566 (1982-04-01), Clitherow et al.
Brittain, Tips, (Nov. 1981), pp. 310-313.

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