Method of making device for arraying biomolecules and for...

Details Method of making device for arraying biomolecules and for... Method of making device for arraying biomolecules and for...

2007-05-01

2007-05-01

Lee, Edmund H. (Department: 1732)

Plastic and nonmetallic article shaping or treating: processes

With printing or coating of workpiece

C264S238000, C264S250000, C264S325000

Reexamination Certificate

active

10206329

ABSTRACT:
The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.

REFERENCES:
patent: 3428184 (1969-02-01), Kuper
patent: 3483976 (1969-12-01), Williams
patent: 4728591 (1988-03-01), Clark et al.
patent: 5256360 (1993-10-01), Li
patent: 6451240 (2002-09-01), Sherman et al.
patent: 6558904 (2003-05-01), Ermantraut et al.

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