Polymeric active methylene compounds, their preparation and thei

Details Polymeric active methylene compounds, their preparation and thei Polymeric active methylene compounds, their preparation and thei

1984-02-17

1985-07-02

Lipman, Bernard

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

5253282, 5253286, 5253333, 525376, 424 81, C08F 830

Patent

active

045269335

ABSTRACT:
Polymer compounds which have recurring ##STR1## units are disclosed. These polymers provide active methylene groups which serve as points of attachment for organic groups--particularly azo functionality-containing groups. These azo links can be cleaved by bacteria in the mammalian lower bowel, thereby releasing the corresponding amino groups. This mechanism can effect programmed delivery of pharmaceutically desirable species to the lower bowel.

REFERENCES:
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patent: 4011201 (1977-03-01), Ponticello
patent: 4296226 (1981-10-01), Braun et al.
C.A., vol. 84, 1976, 84:180840g, Panarin et al.
C.A., vol. 83, 1975, 9544b, Krause et al.
C.A., vol. 80, 1974, 48525d, Plate et al.

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