Polypeptide encoded by a nucleotide sequence of a...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S403000, C424S278100

Reexamination Certificate

active

10795159

ABSTRACT:
The invention relates to the polynucleotide sequence of a nontypeable stain ofHaemophilus influenzae(NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

REFERENCES:
patent: 6797274 (2004-09-01), Ruelle
patent: WO 9924578 (1999-05-01), None
patent: WO0234768 (2002-05-01), None
Green et al. (2005) Certain site-dircted, nonenzymatically active mutants of theHaemophilus influenzaeP4 lipoprotein are able to elicit bactericidal antibodies. Infect. Immun. vol. 73, No. 7, pp. 4454-4457.
Shen et al. (2002) Molecular determinants of disease and resistance in interactions ofXanthomonas oryzaepv. oryzae and rice. Microbes Infect. vol. 4, No. 13, pp. 1361-1367.
Gritsun et al. (1995) Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis. Virus Res. vol. 35, No. 3, pp. 307-321.
Cardillo et al. (2000) Synthesis of the Phenylserine-Leucine Dipeptide Fragment Present in the Antibiotic Lysobactin from an Aziridine-2-imide Precursor, Eur. J. Org. Chem., vol. 2000, No. 13, pp. 2489-2494.
Henriksen et al. (2002) Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. Genes Dev. vol. 16, No. 18, pp. 2379-2389.
Ackerley, et al., “A genome-scale analysis for identification of genes required for growth or survival ofHaemophilus influenzae,” Proc. Natl. Acad. Sci. USA 99(2):966-971 (Jan. 22, 2002).
Altschul, et al., “Basic Local Alignment Search Tool,”J. Mol. Biol. 215: 403-410 (1990).
Anderson, et al., “Quantitative Filter Hybridisation,” Chapter 4: 73-111,Nucleic Acid Hybridisation: A Practical Approach, IRL Press Limited, Oxford, England.
Anderson, P. et al., “Human Serum Activities againstHemophilus influenzae, Type b,”The Journal of Clinical Investigation 51: 31-38 (1972).
Badger, et al., “Identification ofEscherichia coliK1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction,”Molecular Microbiology 36(1): 174-182 (2000).
Bakaletz, et al., “Frequency of Fimbriation of NontypableHaemophilus influenzaeand Its Ability to Adhere to Chinchilla and Human Respiratory Epithelium,”Infect. Immun., 56(2): 331-335 (Feb. 1998).
Bakaletz, et al., “Evidence for Transudation of Specific Antibody into the Middle Ears of Parenterally Immunized Chinchillas after an Upper Respiratory Tract Infection with Adenovirus,”Clinical and Diagnostic Laboratory Immunology 4(2): 223-225 (Mar. 1997).
Bakaletz, et al., “Modeling Adenovirus Type-1 Induced Otitis Media in the Chinchilla: Effect on Ciliary Activity and Fluid Transport Function of Eustachian Tube Mucosal Epithelium,”The Journal of Infectious Diseases 186: 865-72 (1993).
Bakaletz, et al., “Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeableHaemophilus influenzaein the chinchilla,”Vaccine, 15(9): 955-961 (1997).
Bakaletz, et al., “Protection against Development of Otitis Media Induced by NontypeableHaemophilus influenzaeby Both Active and Passive Immunization in a Chinchilla Model of Virus-Bacterium Superinfection,”Infect.Immun. 67(6): 2746-2762 (Jun. 1999).
Baldwin, R.L., “Effects of Otitis Media on Child Development,”The American Journal of Otology 14(6): 601-604 (Nov. 1993).
Baltes, et al., “Actinobacillus pleuropneumoniaeIron Transport and Urease Activity: Effects on Bacterial Virulence and Host Immune Response,”Infect. Immun. 69(1): 472-478 (Jan. 2001).
Barenkamp, et al., “Outer Membrane Protein and Biotype Analysis of Pathogenic NontypableHaemophilus influenzae,” Infect. Immun. 36(2): 535-540 (May 1982).
Bartilson, et al., “Differential fluorescence induction revealsStreptococcus pneumoniaeloci regulated by competence stimulatory peptide,”Molecular Microbiology 39(1): 126-135 (2001).
Berman, et al., “Theoretical Cost Effectiveness of Management Options for Children with Persisting Middle Ear Effusions,”Pediatrics 83(3):353-363 (Mar. 1984).
Black, et al., “Efficacy, safety and immunogenecity of heptavalent pneumococcal conjugate vaccine in children,”Pediatr. Infect. Dis. J. 19(3): 187-195 (2000).
Bosse, et al., “Urease activity may contribute to the ability ofActinobacillus pleuropneumoniaeto establish infection,”The Canadian Journal of Veterinary Research 64: 145-150 (2000).
Bright, et al., “The Prevalence of Tympanostomy Tubes in Children in the United States, 1988,”American Journal of Public Health 83(7):1026-1028 (Jul. 1993).
Chiang, et al., “In vivoGenetic Analysis of Bacterial Virulence,”Annu. Rev. Microbiol. 53: 129-54 (1999).
Chissoe, et al., “Strategies for Rapid and Accurate DNA Sequencing,”Methods: A Companion to Methods in Enzymology 3(1):55-65 (1991).
Cimons, M., “Lurid Reports Obscure Reality of Strep A Outbreak,”ASM News 60(10): 527-528 (1994).
Cormack, et al., “FACS-optimized mutants of the green fluorescent protein (GFP),”Gene 173:33-38 (1996).
Davis, et al., “Liposomes as adjuvants with immunopurified tetanus toxoid: the immune response,”Immunology Letters 14:341-348 (1987).
DeMaria, et al., “Biotypes of Serologically NontypableHaemophilus influenzaeIsolated from the Middle Ears and Nasopharynges of Patients with Otitis Media with Effusion,”J. Clin. Microbiol. 20(6):1102-1104 (Dec. 1984).
DeMaria, et al., “Immunization with Outer Membrane Protein P6 from NontypeableHaemophilus influenzaeInduces Bactericidal Antibody and Affords Protection in the Chinchilla Model of Otitis Media,”Infect. Immun. 64(12):5187-5192 (Dec. 1996).
Devereux, et al., “A comprehensive set of sequence analysis programs for the VAX,”Nucleic Acids Research 12(1):387-395 (1984).
Dhandayuthapani, et al., “Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages,”Molecular Microbiology 17(5):901-912 (1995).
Dunn, et al., “A vector for promoter trapping inBacillus cereus,” Gene 226:297-305 (1999).
Ehrlich, et al., “Mucosal Biofilm Formation on Middle-Ear Mucosa in the Chinchilla Model of Otitis Media,”JAMA 287(13):1710-1715 (Apr. 3, 2002).
Erickson, et al. Chapter 3: “Solid-Phase Peptide Synthesis” inThe Proteins,v.2, Academic Press, New York: 255-527 (1976).
Eskola, et al., “Potential of bacterial vaccines in the prevention of acute otitis media,”Pediatr Infect Dis J 19(5):72-78 (2000).
Eskola, et al., “Efficacy of a Pneumococcal Conjugate Vaccine Against Acute Otitis Media,”N Engl J Med 344(6):403-409 (Feb. 8, 2001).
Eskra, et al., “Brucella abortusGenes Identified following Constitutive Growth and Macrophage Infection,”Infect. Immun. 69(12):7736-7742 (Dec. 2001).
Fleischmann et al., “Histidine biosynthesis bifunctional protein hisB,” UNIPROT: HIS7—HAEIN, Database accession No. P44327 (1995).
Fleischmann et al., “Whole-Genome Random Sequencing and Assembly ofHaemophilus influenzaeRd,”Science 269: 496-512 (Jul. 28, 1995).
Fleischmann et al., “Haemophilus influenzaeRd KW20 section 45 of 163 of the complete geneome,” EMBL: H132730, Database accession No. U32730, L42023 (1995).
Giebank, G.S., “Immunology: promise of new vaccines,”Pediatr Infect Dis J 13(11): 1064-1068 (Nov. 1994).
Goosen, et al., “The regulation of transcription initiation by integration host factor,”Molecular Microbiology 16(1):1-7 (1995).
Holmes, et al., “Adherence of non-typeableHaemophilus influenzaepromotes reorganization of the actin cytoskeleton in human o

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