Nephrotoxicity inhibitors for aminoglycoside antibiotics

Details Nephrotoxicity inhibitors for aminoglycoside antibiotics Nephrotoxicity inhibitors for aminoglycoside antibiotics

1983-04-29

1985-07-02

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 42, 514 25, 2601125R, 260112R, 424 78, A61K 3700, A61K 3170, C07G 700, C07C10352

Patent

active

045268886

ABSTRACT:
This invention relates to the conjoint use of asparagine or aspartic acid polymers, e.g. poly-l-asparagine or poly-l-aspartic acid polymers, or copolymers thereof, with aminoglycoside antibiotics to inhibit the nephrotoxicity associated with aminoglycoside antibiotics.

REFERENCES:
patent: 3927204 (1975-12-01), Neri et al.
patent: 4356166 (1982-10-01), Peterson et al.
patent: 4409247 (1983-10-01), Baret et al.
Josepovitz et al., J. Pharm. and Exp. Ther. vol. 223, pp. 314-321, (1982).
Lipsky, J. J. J. Pharm. and Exp. Ther. vol. 215, pp. 390-393, (1980).
Kornguth et al. J. Antimicrobial Chemotherapy vol. 6, pp. 121-131, 1980.
Friedmann et al., Chemical Abstracts, vol. 94, No. 140387x, 1981 "Polymers with Potential Pharmacological Properties".

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