Substituted heteroaryl and heterocyclic compounds useful in...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S365000, C514S415000, C514S422000, C544S133000, C548S146000, C548S469000, C548S518000

Reexamination Certificate

active

10612187

ABSTRACT:
This invention is directed to substituted heteroaryl and heterocyclic compounds as nicotinamide adenine dinucleotide oxidase hydride donor inhibitors useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.

REFERENCES:
patent: WO 96/13264 (1996-05-01), None
patent: WO 96/13264 (1996-05-01), None
patent: WO 98/15274 (1998-04-01), None
patent: WO 99/18091 (1999-04-01), None
Lau et al. “Evolution of a Series of Non-Qinoline Leukotriene D4 Receptor Antagonist; Synthesis and SAR of Benzothiazoles and Thiazoles Substituted Benzyl Alcohols as Potent LTD4 Antagonists” Biorganic & Medicinal Chemistry Letters, 1995, 1615-1620.
McMurry, John “Organic Chemistry—Fourth Edition” Brooks/Cole Publishing Company, 1996, pp. 377-385, 603-604, 679-680, and 946-947.
Malamas M.S. et al., “Azole phenoxy hydroxyureas as selective and orally active inhibitors to 5-lipoxygenase”, Journal of Medicinal Chemistry, vol. 39, No. 1, Jan. 5, 1996.
PCT International Search Report, dated Dec. 19, 2003, for PCT Appln. No. PCT/US03/20781.

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