Four-helical bundle protein zsig81

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C530S326000, C530S328000, C530S350000, C536S023500, C435S320100, C435S325000, C435S252300

Reexamination Certificate

active

10315379

ABSTRACT:
This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of hematopoietic cells and will be useful expansion of these cells, as well as conditions associated with hematopoietic cells. The invention is directed to antibodies and methods of making zsig81 polypeptides, as well.

REFERENCES:
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Chaiken et al. Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design. Trends Biotechnol. Oct. 1996;14(10):369-75.
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Ngo et al., “In The Protein Folding Problem and Tertiary Structure Prediction,” Merz and Le Grand (eds), Springer Verlag, pp. 433 and 492-1495, 1994.

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