Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Reexamination Certificate
2007-02-13
2007-02-13
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
C424S001110, C424S001650, C424S001810, C424S009100, C424S009200
Reexamination Certificate
active
10319812
ABSTRACT:
The use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labeled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging is described. The method can be used to monitor delivery of antitumor drugs to tumors, to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g.,11C-paclitaxel and11C-docetaxel, labeled anthracyclines, e.g.,11C-doxorubicin and11C-epirubicin, and other radiolabeled drugs, e.g.11C-topotecan,11C-SN-38, and11C-imatinib. The invention further describes antitumor drugs labeled with the radioactive label11C and methods of preparing radio-labeled drugs.
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Anderson Lawrence W.
Collins Jerry M.
Klecker, Jr. Raymond W.
Haddaway Keith G.
Jones Dameron L.
The United States of America as represented by the Secretary of
Venable LLP
Wiseman Thomas G.
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