Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-01-23
2007-01-23
Kaushal, Sumesh (Department: 1633)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S320100, C435S325000, C435S455000, C536S023100, C536S023500, C530S350000, C530S351000
Reexamination Certificate
active
09925674
ABSTRACT:
The present invention is broadly directed to therapeutic molecules capable of inter alia modulating apoptosis in mammalian cells. The therapeutic molecules of the present invention encompass genetic sequences and chemical entities capable of regulating expression of a novel mammalian gene belonging to the bcl-2 family and which promotes cell survival. The therapeutic molecules of the present invention may have further utility in delaying cell cycle entry. In addition, the present invention extends to chemical entities capable of modulating activity and function of the translation product of said novel gene of the bcl-2 family. The present invention also extends to the translation product of the novel gene of the bcl-2 family and its use in, for example, therapy, diagnosis, antibody generation and as a screening tool for therapeutic molecules capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
REFERENCES:
patent: 5789201 (1998-08-01), Guastella
patent: 6812339 (2004-11-01), Venter et al.
patent: 0 252 685 (1988-01-01), None
patent: WO 95/00642 (1995-01-01), None
Ke et al, Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. Ke at al, J. Biol. Chem., 276(16):12481-12484, 2001.
Ngo, Computational complexity Protein structure prediction and the Levinthal paradox in The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser Boston, MA, pp. 433 and 492-495, 1994).
Rudinger Characteristics of amino acids as components of a peptide hormone sequence (in Peptide Hormones, Parsons (ed.), University Park Press: Baltimore, MD, pp. 1-7, 1976).
PTO sequence search report Oct. 28, 2003 showing sequence compression with US 5789201.
AN: Q92843, BCLW—HUMAN, 1997 PTO sequence search report Apr. 2005.
AN: P70345, BCLW—MOUSE, 1997 PTO sequence search report Apr. 2005.
US: 6812339, SEQ ID NO:10928, PTO sequence search report Apr. 2005.
Boise, L. H., et al. (1993)Cell,74:597-608.
Brand, S. F., et al. (1995)Gene,154:187-192.
Chittenden, T., et al. (1995)The EMBO Journal,14:5589-5596.
Chittenden, T., et al. (1995)Nature,374:733-736.
Cruz-Reyes, J., et al. (1995)Gene,158:171-179.
Fang, W., et al. (1994)Cloning of Mouse,4388-4398.
Farrow, S. N., et al. (1995)Nature,374:731-733.
Gibson, L., et al. (1996)Oncogene,13:665-675.
Hockenbery, D. M., et al. (1991)Proc. Natl. Acad. Sci. USA,88:6961-6965.
Kiefer, M. C., et al. (1995)Nature,374:736-739.
Oltvai, Z. N., et al. (1993)Cell,74:609-619.
Subramanian, T., et al. (1995)Oncogene,11:2403-2409.
Yin, X. M., et al. (1994)Nature,369:321-323.
Adams Jerry McKee
Cory Suzanne
Gibson Leonie M.
Holmgreen Shaun P.
Kaushal Sumesh
Scully, Scott, Murphy & Presser, P. C.
The Walter and Eliza Hall Institute of Medical Research
LandOfFree
Mammalian gene, bcl-w, belongs to the bcl-2 family of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mammalian gene, bcl-w, belongs to the bcl-2 family of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mammalian gene, bcl-w, belongs to the bcl-2 family of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3814086