Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-05-08
2007-05-08
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C436S501000
Reexamination Certificate
active
10504726
ABSTRACT:
By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
REFERENCES:
patent: 2004/0137517 (2004-07-01), Andrews et al.
patent: WO 00/22129 (2000-04-01), None
patent: WO 02/057783 (2002-07-01), None
patent: WO-02/061087 (2002-08-01), None
patent: WO 02/061087 (2002-08-01), None
Sawzdargo et al, “A Cluster of Four Novel Human G Protein-Coupled Receptor Genes Occurring in Close Proximity to CD22 Gene on Chromosomes 19q13.1,”Biochemical and Biophysical Research Communications239:543-547 (1997).
Y. Itoh, et al., “Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40”,Nature, vol. 422, No. 6928, Mar. 13, 2003, pp. 173-176.
M. Sawzdargo, et al., “Identification and cloning of three novel human G protein-coupled receptor genes GPR52, ψGPR53 and GPR55: GPR55 is extensively expressed in human brain”,Molecular Brain Research, vol. 64, No. 2, Feb. 5, 1999, pp. 193-198.
R. P. Robertson, “Eicosanoids as Pluripotential Modulatos of Pancreatic Islet Function”, Diabetes, vol. 37, No. 4, 1998, pp. 367-370.
Fujii Ryo
Harada Masataka
Hinuma Shuji
Hosoya Masaki
Ito Yasuaki
Conlin David G.
Edwards Angell Palmer & & Dodge LLP
Takeda Pharmaceutical Company Limited
Ulm John
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