Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-06-19
2007-06-19
Saeed, Kamal (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S363000, C544S114000, C548S139000
Reexamination Certificate
active
11078867
ABSTRACT:
The present invention relates to compounds of the Formula Iwherein R1, R3, R5, R7, X, Y and U are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods of treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
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Mazzone et al., “Synthesis and Local Anesthetic Activity of Alkylaminoacyl Derivatives of 2-amino-1,3,4-thiadiazole,” Farmaco, 48(9), pp. 1207-1224 (1993).
El-Sherbeny et al., “Local Anesthetic and Antiarrhythmic Activity of Certain New 1,3,4-thiadiazole Derivatives,” Saudi Pharmaceutical J., 6(3-4), pp. 228-234 (1998).
Mazzone et al., “Synthesis and Local Anesthetic Activity of Alkylaminoacyl Derivatives of 2-amino-1,3,4-thiadiazole,” Farmaco, 48(9), pp. 1207-1224 (1993).
El-Sherbeny et al., “Local Anesthetic and Antiarrhythmic Activity of Certain New 1,3,4-thiadiazole Derivatives,” Saudi Pharmaceutical J., 6(3-4), pp. 228-234 (1998).
Kurihara et al, “Synthesis of 2(or 2,5-di)-substituted 1,3,4-thiadiazole derivatives,” Yakugaku Zasshi, 85(10), pp. 920-925 (1965).
Kurihara et al., STN International, HCAPLUS Database, Columbus, OH, Accession No. 1966:4154, Reg. Nos. 4447-39-6 and 4994-32-5 (2006).
Mazzone, Gioacchino et al, Synthesis and Local Anesthetic Activity of Alkylaminoacyl Derivatives of 2-amino-1,3,4-thiadazole, p. 1215; table IV; compounds 29, 34, 35, 40, 41 and p. 1216; table V; compounds 52, 53, 58, 59, 65 and p. 1217; table VI; compounds 76, 81, 82, 87, 88.
El-Sherberry, Magda A. et al, Local Anesthetic and Antiarrhythmic Activity of Certain New 1,3,4-thiadiazole Derivatives, Saudi Pharmaceutical Journal, 6(3-4), 228-234, 1998.
Mazzone, Gioacchino et al, Synthesis and Local Anesthetic Activity of Alkylaminoacyl Derivatives of 2-amino-1,3,4-thiadiazole, p. 1215; table IV; compounds 29, 34, 35, 40, 41 and p. 1216; table V; compounds 52, 53, 58, 59, 65 and p. 1217; table VI; compounds 76, 81, 82, 87, 88. (1993).
El-Sherbeny, Magda A. et al, Local Anesthetic and Antiarrhythmic Activity of Certain New 1,3,4-thiadiazole Derivatives, Saudi Pharmaceutical Journal, 6(3-4), 228-234, 1998.
Freistein Andrew B.
Kershner David L.
Pfizer Inc
Saeed Kamal
Zelson Steve
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