Pharmaceutical combination composition and associated method

Details Pharmaceutical combination composition and associated method Pharmaceutical combination composition and associated method

1984-02-17

1985-07-02

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514960, A61K 922

Patent

active

045267774

ABSTRACT:
A novel combination pharmaceutical composition is described, together with a method for making the same, wherein the pharmaceutically active ingredients are separately milled and then formed into separate granules, and only thereafter blended together to form the combination composition. The method for achieving this novel combination composition is also described. In particular, a novel combination composition of triamterene and hydrochlorothiazide having improved bioavialability and novel effectiveness to prevent or eliminate hypokalemic side effects is also described.

REFERENCES:
patent: 2853418 (1958-09-01), Smith
patent: 3146167 (1964-08-01), Lantz et al.
patent: 3220025 (1966-11-01), Schroeder
patent: 4139589 (1979-02-01), Beringer et al.
patent: 4168308 (1979-09-01), Wretlind
patent: 4169885 (1979-10-01), Raaf et al.
patent: 4255413 (1981-03-01), Ratti
patent: 4285947 (1981-08-01), Higuchi
Remington's Pharmaceutical Science 16, 1980 pp. 1553-1557.

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