Process for producing a dipeptidyl peptidase IV inhibitor

Details Process for producing a dipeptidyl peptidase IV inhibitor Process for producing a dipeptidyl peptidase IV inhibitor

2007-05-08

2007-05-08

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S452000

Reexamination Certificate

active

11135217

ABSTRACT:
A process is provided for preparing the dipeptidyl peptidase of the structure I(also referred to as saxaglipitin)by direct dehydration, in one pot, of the amide IIby reacting amide II with phosphorus oxychloride in an organic solvent such as dichloromethane, quenching the reaction mixture with water to form the hydrochloric acid salt of I, and treating the hydrochloric acid salt with base to form the free base of I.

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