Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-10
2007-04-10
Epperson, Jon (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
10287434
ABSTRACT:
This invention relates to the enzymatic synthesis of oligophenols on solid support by sequential enzymatic addition of reaction solutions containing phenols. The oligomers are then selectively built up on the solid surface. When used in a specific format, the oligomers can be generated in a spatially addressable array, which can then be screened for some type of biological interaction. The synthetic compounds of the present invention are synthesized in a combinatorial manner on solid support using peroxidase or other related enzymatic catalysis, and the products are generated in spatially addressable microarrays. Oligophenols of the present invention have shown significance as potential inhibitors of NADPH oxidase assembly, an enzyme that has been implicated in a wide range of diseases stemming from vascular hyperpermeability.
REFERENCES:
patent: 5902831 (1999-05-01), Holland et al.
patent: 5919523 (1999-07-01), Sundberg et al.
patent: 6025371 (2000-02-01), Gordeev et al.
patent: 6090912 (2000-07-01), Lebl et al.
patent: 6251689 (2001-06-01), Laborde et al.
patent: 6274383 (2001-08-01), Gao
patent: 2001/0017269 (2001-08-01), Heller et al.
patent: 2002/0185184 (2002-12-01), O'Connor et al.
patent: WO 9525737 (1995-10-01), None
Iwahara, K.; Honda, Y.; Watanabe, T.; Kuwahara, M. “Polymerization of guaiacol by lignin-degrading manganese peroxidase from Bjerkandera adusta in aqueous organic solvents” Appl. Microbiol. Biotechnol. Jul. 2000, 54, 104-111.
Suckau, D.; Koster, C.; Hufnagel, P.; Drauter, K.-O.; Rapp, U. “Automation of MALDI-TOF Analysis for Proteomics” Application Note #MT-50. 1999, 1-5.
Alam et al. “DNA-Binding Peptides Search from the Solid-Phase Combinatorial Library with the Use of the Magnetic Beads Attaching the Target Duplex DNA” Bioorganic & Medicinal Chemistry 2000, 8, 465-473.
Wu, et al. “Enzymatically and Combinatorially Generated Array-Based Polyphenol Metal Ion Sensor” Biotechnol. Prog. 2000, 16, 513-516 US-.
Solomons, T. W. G. Organic Chemistry Fifth Edition. New York: John Wiley and Sons. 1992, pp. 942 and 943.
Heistand II et al. “Catecholate and Phenolate Iron Complexes as Models for the Dioxygenases” J. Am. Chem. Soc. 1982, 104, 2789-2796.
Haswell, S.J., et al., “Chemical and Biochemical Microreactors,”Trends in Analytical Chemistry, 19(6): 389-395 (2000).
Drott, J., et al., “Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities,”J. Micromech. Microeng., 7: 14-23 (1997).
Laurell, T., et al., “Silicon wafer integrated enzyme reactors,”Biosensors&Bioelectronics, 10: 289-299 (1995).
Nagy, G., et al., “Amperometric Microcell for Enzyme Activity Measurements,”Analytical Chemistry, 70(10):2156-2162 (1998).
Dordick Jonathan S.
Hogg Michael G.
Holland James A.
Santhanam Lakshmi
Epperson Jon
Hamilton Brook Smith & Reynolds P.C.
Rensselaer Polytechnic Institute
The United States of America as represented by the Secretary, De
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