Diterpene-producing unicellular organism

Details Diterpene-producing unicellular organism Diterpene-producing unicellular organism

2007-07-03

2007-07-03

Ramirez, Delia M. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S193000, C435S232000, C435S320100, C435S325000, C435S254200, C435S254210, C435S069100, C435S041000, C530S350000, C536S023200

Reexamination Certificate

active

10041018

ABSTRACT:
The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synthase, an inducible nucleic acid sequence encoding a soluble form of HMG-CoA reductase, a nucleic acid sequence of an allele that confers an increase in sterol metabolic flux and, in the diterpene-producing cell, a diterpene synthase.

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