Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2007-04-24
2007-04-24
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S130100, C424S133100, C424S135100, C424S141100, C424S147100, C424S164100, C424S178100
Reexamination Certificate
active
09848377
ABSTRACT:
Therapeutically effective anti-viral compositions, useful especially against respiratory diseases caused or mediated by respiratory syncytial virus (RSV) are disclosed, wherein said compositions comprise at least one anti-RSV antibody, including high affinity antibodies, and an additional anti-inflammatory agent, especially corticosteroids, as well as anti-inflammatory antibodies, especially anti-interleukin-6. Also disclosed are methods of using such compositions to treat and/or prevent respiratory diseases. Such compositions may optionally contain other non-antibody anti-viral agents.
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patent: WO 01/82966 (2001-11-01), None
Johnson et al., The Journal of infectious Diseases, 180: 35-40, 1999.
Smyth et al., Immunological responses to respiratory syncytial virus infection in infancy Arch Dis Child 1997 76: 210-214.
Prince, G.A., “Respiratory Syncytial Virus Antiviral Agents”, Expert Opinion on Therapeutic Patents, pp. 753-762, 9/6 (1999).
Ottolini, M.G., et al., “Prevention and Treatment Recommendations for Respiratory Syncytial Virus Infection Background and Clinical Experience 40 years after Discovery,” in Drugs, 54/6, pp. 867-884, (1997).
Jiang, Zili, et al., “Autocrine Regulation and Experimental Modulation of Interleukin-6 Expression by Human Pulmonary Epithelial Cells Infected with Respiratory Syncytial Virus”, Journal of Virology, vol. 72, No. 3, Mar. 1998, pp. 2496-2499.
Prince, Gregory, et al., “Treatment of Respiratory Syncytial Virus Bronchiolitis and Pneumonia in a Cotton Rat Model with Systemically Administered Monoclonal Antibody (Palivizumab) and Glucocorticosteroid”, Journal of Infectious Diseases, vol. 182, No. 5, Nov. 2000, pp. 1326-1330.
Bulow et al., Prednisolone treatment of Respiratory Syncytial Virus Infection: a randomized controlled trial of 147 infants,Pediatrics, 104 (Dec. 6, 1999), p. e77).
Johnson Leslie S.
Prince Gregory
Campell Bruce R.
Grant Alan J.
Hill Myron G.
MedImmune, Inc.
Olstein Elliot M.
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