Control of gene expression

Details Control of gene expression Control of gene expression

2007-04-10

2007-04-10

Zara, Jane (Department: 1635)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S091100, C435S455000, C436S501000, C536S023100, C536S023400, C536S024100, C536S024500

Reexamination Certificate

active

10019520

ABSTRACT:
A method of suppressing the expression of a selected gene in a eukaryotic cell the method comprising introducing into the cell (a) a polypeptide comprising a DNA binding portion which binds to a site at or associated with the selected gene which site is present in a plant r animal genome and a chromatin inactivation portion, or (b) a polynucleotide encoding said polypeptide.

REFERENCES:
patent: WO 96/06166 (1996-02-01), None
patent: WO 98/53057 (1998-11-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/02683 (1999-01-01), None
patent: WO 99/23885 (1999-05-01), None
patent: WO 00/41566 (2000-07-01), None
patent: WO 00/42219 (2000-07-01), None
patent: WO 00/73434 (2000-12-01), None
patent: WO 01/00815 (2001-01-01), None
Pooga, M. et al., FASEB J., vol. 12, pp. 67-77 (1998).
Elliot, G. et al., Cell, vol. 88, pp. 223-233 (1997).
Derossi, D., J. Biol. Chem., vol. 269, No. 14, pp. 10,444-10450 (1994).
Grignani, F. et al., Nature, vol. 391, pp. 815-818 (1998).
Chien, P.-Y., et al., Molecular Endocrinology, vol. 13, No. 12, pp. 1161-1167 (1998).
Grignani et al, NATURE,Fusion Proteins of the Retinoic Acid receptor-a Recuit Histone Deacetylase in Promyelocytic Leukaemia, vol. 391, Feb. 19, 1998, pp. 815-818.
Kevin Struhl, Genes & Development,Histone acetylation and Transcriptional Regulatory Mechanisms, 1998, 12:599-606.
Beerli et al, National Academy of Sciences,Toward Controlling Gene Expression at Will: Specific Regulation of the erbB-2/HER-2 Promotor by Using Polydactyl Zinc Finger Proteins Constructed From Modular Building Blocks, 1998, pp. 14628-14633.
Hsieh et al, National Academy of Sciences,CIR, a Corepressor Linking the DNA binding factor CBF1 to the Histone Deacetylase Complex, pp. 23-28.
Chien et al, Molecular Endocrinology,A Fusion Protein of the Estrogen Receptor(ER)and Nuclear Receptor Corepressor(NcoR)Strongly Inhibits Estrogen-Dependent Responses in Breast Cancer Cells, vol. 13, No. 12, 1999, pp. 2122-2136.
Chen et al, EMBO Journal,Fusion Between a Novel Kruppel-Like Zinc Finger Gene and the Retinoic Acid Receptor-a Locus Due to a Variant t(11;17)Translocation Associated with Acute Promyelocytic Leukaemia, vol. 12 No. 13, 1993, pp. 1161-1167.
Grozinger et al, National Academy of Sciences,Three Proteins Define a Class of Human Histone Deacetylases Related to Yeast Hdalp, vol. 96, Apr. 1999 pp. 4868-4873.
Guidez et al, BLOOD,Reduced Retinoic Acid-Sensitive of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARa Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia, vol. 91, Apr. 15, 1998, pp. 2634-2642.
Tora et al, EMBO Journal,The Cloned Human Oestrogen Receptor Contains a Mutation Which Alters its Hormone Binding Properties, vol. 8, No. 7, pp. 1981-1986, 1989.
Tilley et al, National Academy of Sciences,Characterization and Expression of a cDNA Encoding the Human Androgen Receptor, vol. 86, Jan. 1989, pp. 327-331.
Aharon Razin, EMBO Journal,CpG Methylation, Chromatin Sructure and Gene Silencing-a Three-Way Connection, vol 17, 1998, pp. 4905-4908.
David et al, ONCOGENE,Histone Deacetylase Associated with mSin3A Mediates Repression by the Acute Promyelocytic Leukemia-Associated PLZF Protein, (1998), 16, pp. 2549-2556.
Lin et al, NATURE,Role of the Histone Deacetylase Complex in Acute Promyelocytic Leukaemia, vol. 391, Feb. 19, 1998, pp. 811-814.
Horlein et al, NATURE,Ligand-Independent Repression by the Thyroid Hormone Receptor Mediated by a Nuclear Receptor Co-Repressor, vol. 377, Oct. 5, 1995, pp. 397-405.
Chen and Li, Critical Reviews,Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors, 8 (2), 1998, pp. 169-190.
Workman and Kingston, Annu. Rev. Biochem.,Alteration of Nucleosome Structure as a Mechanism of Transcriptional Regulation, 1998, 67:545-79.
Perlmann and Vennstrom, NATURE,The Sound of Silence, vol. 377, Oct. 5, 1995, pp. 387-389.
Wolffe, NATURE,Sinful Repression, vol. 387, May 1, 1997, pp. 16-17.
Grunstein et al, NATURE,Histone Acetylation in Chromatin Structure and Transcription, Sep. 25, 1997, vol. 389 pp. 349-353.
Pazin and Kadonaga, CELL,What's Up and Down With Histone Deacetylation and Transcription, vol. 89, May 2, 1997, pp. 325-328.
DePinho, NATURE,The Cancer-Chromatin Connection, vol. 391, Feb. 5, 1998, pp. 532-537.
Bestor, NATURE,Methylation Meets Acetylation, vol. 393, May 28, 1998, pp. 311-313.
Grunstein, CELL,Yeast Heterochromatin: Regulation of Its Assembly and Inheritance by Histones, vol. 93, May 1, 1998, pp. 325-328.
Margolin, National Academy Sciences,Kruppel-Associated Boxes are Potent Transcriptional Repression Domains, vol. 91 May 1994, pp. 4509-4513.
Schultz et al, Genes and Development,Targeting Histone Deacetylase Complexes via KRAB-Zinc Finger Proteins: The PHD and Bromodomains of KAP-1 Form a Cooperative Unit That Recruits a Novel Isoform of the MI-2A Subunit of NURD, 2001, 15:428-443.
Kim et al, Proc. National Academy Sciences,A Novel Member of the Ring Finger Family, KRIP-1, Associates With the KRAB-A Transcriptional Repressor Domain of Zinc Finger Proteins, vol. 93, Dec. 1996, pp. 15299-15304.
Lin et al, Biochemical and Biophysical Research Communications,Catonic Liposome-mediated Incorporation of Prostatic Acid Phosphatase Protein Into Human Prostate Carcinoma Cells, vol. 192, No. 2, 1993, pp. 413-419.
Chu et al, Pharmaceutical Research,Efficiency of Cytoplasmic Delivery by pH-Sensitive Liposomes to Cells in Culture, vol. 7, No. 8, 1990, pp. 824-834.
Lindgren et al, Trends in Pharmacological Science,Cell-penetrating Peptides, vol. 21, 2000, pp. 99-103.
Jacek Hawiger, Current Opinion in Chemical Biology,Noninvasive Intracellular Delivery of Functional Peptides and Proteins, vol. 3, 1999, pp. 89-84.

Affiliated with

Also associated with

Rating

Control of gene expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Control of gene expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Control of gene expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3799485