Substituted stilbene compounds with vascular damaging activity

Details Substituted stilbene compounds with vascular damaging activity Substituted stilbene compounds with vascular damaging activity

Filed on

2007-09-04

Date issued

2007-09-04

Examiner

Aulakh, Charanjit S. (Department: 1625)

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

C546S304000, C564S017000, C564S026000, C564S225000, C562S439000, C562S440000, C560S019000, C514S534000, C514S585000, C514S631000

Type

Reexamination Certificate

Status

active

Patent number

09890990

Description

ABSTRACT:
A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of the formation or action of nitric acid. Also, a method for inducing necrosis in vasculature of a tumor in an animal by administering to the animal the compound in an amount effective for inducing the necrosis.

REFERENCES:
patent: 0641767 (1995-03-01), None
patent: 92/16486 (1992-10-01), None
Ohsumi, Koji, et al. “Novel Combretastain Analogues Effective against Murine Solid Tumors: Design and Structure-Activity Relationships” J. Med. Chem. (1998) vol. 41, No. 16 pp. 3022-3032.
Ohsumi, Koji, et al. “Syntheses and Antitumor Activity of Cis-Restricted Combretastatins: 5-Membered Heterocyclic Analogues.” Bioorg. Med. Chem. Lett 8 (1998) pp. 3153-3158.
Pettit, George R., et al. “Antineoplastic agents 322. Synthesis of Combretastatin A-4 prodrugs” Anti-Cancer Drug Design (1995) vol. 10, No. 4 pp. 299-309.
Folkman, Judah, “Clinical Applications of Research on Angiogenesis” Seminars in Medicine of the Beth Israel Hospital, Boston (1995) vol. 333 No. 26 pp. 1757-1763.
Dark, Graham G., et al. “Combretastatin A-4, an Agent That Displays Potent and Selective Toxicity toward Tumor Vasculature1” Cancer Research (1997) vol. 57 pp. 1829-1834.
Chinje, E.C., et al., “Role of nitric oxide in growth of solid tumours: a balancing act”Essays in Biochemistry, vol. 32, pp. 61-72 (1997).

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