Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-01
2007-05-01
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S375100
Reexamination Certificate
active
10608333
ABSTRACT:
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors having at least one oxime group or hydrazone group and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor having at least one oxime group or hydrazone group, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor having at least one oxime group or hydrazone group, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention having at least one oxime group or hydrazone group can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.
REFERENCES:
patent: 5134142 (1992-07-01), Matsuo et al.
patent: 5409944 (1995-04-01), Black et al.
patent: 5436265 (1995-07-01), Black et al.
patent: 5466823 (1995-11-01), Talley et al.
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5504215 (1996-04-01), Talley et al.
patent: 5508426 (1996-04-01), Talley et al.
patent: 5510368 (1996-04-01), Lau et al.
patent: 5510496 (1996-04-01), Talley et al.
patent: 5516907 (1996-05-01), Talley et al.
patent: 5521207 (1996-05-01), Graneto
patent: 5536752 (1996-07-01), Ducharme et al.
patent: 5550142 (1996-08-01), Ducharme et al.
patent: 5550147 (1996-08-01), Matsuo et al.
patent: 5580985 (1996-12-01), Lee et al.
patent: 5604253 (1997-02-01), Lau et al.
patent: 5604260 (1997-02-01), Guay et al.
patent: 5616601 (1997-04-01), Khanna et al.
patent: 5620999 (1997-04-01), Weier et al.
patent: 5621000 (1997-04-01), Arena et al.
patent: 5639780 (1997-06-01), Lau et al.
patent: 5670533 (1997-09-01), Matsuo et al.
patent: 5677318 (1997-10-01), Lau
patent: 5681842 (1997-10-01), Dellarai et al.
patent: 5698584 (1997-12-01), Black et al.
patent: 5700947 (1997-12-01), Del Soldato
patent: 5703073 (1997-12-01), Garvey et al.
patent: 5710140 (1998-01-01), Ducharme et al.
patent: 5733909 (1998-03-01), Black et al.
patent: 5750558 (1998-05-01), Brooks et al.
patent: 5753688 (1998-05-01), Talley et al.
patent: 5756531 (1998-05-01), Brooks et al.
patent: 5760068 (1998-06-01), Talley et al.
patent: 5776967 (1998-07-01), Kreft et al.
patent: 5776984 (1998-07-01), Dellaria et al.
patent: 5780495 (1998-07-01), Del Soldato
patent: 5789413 (1998-08-01), Black et al.
patent: 5807873 (1998-09-01), Nicolai et al.
patent: 5824699 (1998-10-01), Kreft et al.
patent: 5830911 (1998-11-01), Failli et al.
patent: 5849943 (1998-12-01), Atkinson et al.
patent: 5859257 (1999-01-01), Talley
patent: 5861419 (1999-01-01), Dube et al.
patent: 5861426 (1999-01-01), Del Soldato et al.
patent: 5908858 (1999-06-01), Kimura et al.
patent: 5925631 (1999-07-01), Black et al.
patent: 5945539 (1999-08-01), Haruta et al.
patent: 5968958 (1999-10-01), Guay et al.
patent: 5994381 (1999-11-01), Haruta et al.
patent: 6040341 (2000-03-01), Del Soldato et al.
patent: 6043233 (2000-03-01), Garvey et al.
patent: 6048858 (2000-04-01), Garvey et al.
patent: 6051588 (2000-04-01), Garvey et al.
patent: 6057347 (2000-05-01), Garvey et al.
patent: 6083515 (2000-07-01), Garvey et al.
patent: 6083969 (2000-07-01), Ferro et al.
patent: 6143734 (2000-11-01), Garvey et al.
patent: 6573252 (2003-06-01), Del Soldato
patent: 6649629 (2003-11-01), Bandarage et al.
patent: 2003/0028026 (2003-02-01), Del Soldato
patent: 2003/0171393 (2003-09-01), Del Soldato
patent: 2003/0203899 (2003-10-01), Del Soldato et al.
patent: 2004/0023890 (2004-02-01), Del Soldato
patent: 2004/0023933 (2004-02-01), Del Soldato et al.
patent: 2004/0071177 (2004-04-01), Trespidi et al.
patent: 2004/0082652 (2004-04-01), Del Soldato et al.
patent: 2004/0171592 (2004-09-01), Del Soldatro
patent: 2004/0171682 (2004-09-01), Del Soldato et al.
patent: 0 554 829 (1993-08-01), None
patent: 0 418 845 (1995-08-01), None
patent: 0 745 596 (1996-12-01), None
patent: 0 863 134 (1998-09-01), None
patent: 1 006 114 (2000-06-01), None
patent: WO 94/04484 (1994-03-01), None
patent: WO 94/12463 (1994-06-01), None
patent: WO 94/15932 (1994-07-01), None
patent: WO 94/27980 (1994-12-01), None
patent: WO 95/00501 (1995-01-01), None
patent: WO 95/09831 (1995-04-01), None
patent: 95/15315 (1995-06-01), None
patent: 95/15317 (1995-06-01), None
patent: 95/15318 (1995-06-01), None
patent: WO 95/15316 (1995-06-01), None
patent: WO 95/30641 (1995-11-01), None
patent: 96/03388 (1996-02-01), None
patent: 96/09293 (1996-03-01), None
patent: WO 96/25405 (1996-08-01), None
patent: WO 96/31509 (1996-10-01), None
patent: WO 96/32946 (1996-10-01), None
patent: WO 97/03953 (1997-02-01), None
patent: 97/11704 (1997-04-01), None
patent: 97/13755 (1997-04-01), None
patent: 11704 (1997-04-01), None
patent: 97/27181 (1997-07-01), None
patent: WO 97/28121 (1997-08-01), None
patent: WO 97/31654 (1997-09-01), None
patent: WO 97/34882 (1997-09-01), None
patent: WO 97/38986 (1997-10-01), None
patent: WO 97/40012 (1997-10-01), None
patent: 98/11080 (1998-03-01), None
patent: WO 98/09948 (1998-03-01), None
patent: 98/22442 (1998-05-01), None
patent: WO 98/21195 (1998-05-01), None
patent: 98/46594 (1998-10-01), None
patent: WO 98/47871 (1998-10-01), None
patent: WO 98/47890 (1998-10-01), None
patent: WO 99/10331 (1999-03-01), None
patent: WO 99/10332 (1999-03-01), None
patent: WO 99/12930 (1999-03-01), None
patent: WO 99/14194 (1999-03-01), None
patent: WO 99/14195 (1999-03-01), None
patent: WO 99/44585 (1999-09-01), None
patent: WO 99/45004 (1999-09-01), None
patent: 99/64415 (1999-12-01), None
patent: WO 00/06585 (2000-02-01), None
patent: WO 00/25776 (2000-05-01), None
patent: WO 00/44705 (2000-08-01), None
patent: WO 00/51988 (2000-09-01), None
patent: WO 00/61537 (2000-10-01), None
patent: WO 00/61541 (2000-10-01), None
patent: WO 00/61549 (2000-10-01), None
patent: WO 00/61604 (2000-10-01), None
patent: 2000/066562 (2000-11-01), None
patent: 66562 (2000-11-01), None
patent: WO 00/72838 (2000-12-01), None
patent: WO 01/12584 (2001-02-01), None
patent: WO 01/81332 (2001-11-01), None
patent: WO 04/000300 (2003-12-01), None
patent: WO 04/000781 (2003-12-01), None
patent: 2004/043934 (2004-05-01), None
Freston, The American Journal of Medicine, 107 (6A): 78S-89S (1999).
Naesdal et al., European Journal Gastroenterology & Hepatology, 13(12): 1401-1406 (2001).
Database CAPLUS on STN, Acc. No. 1997:527369, from Emam, Phosphorous, Sulfur and Silicon and the Related Elements, 119:249-256 (1996).
Desiraju et al;Molecules.; 5(7): 945-955 (2000).
Garvey David S.
Ranatunge Ramani R.
Richardson Stewart K.
NitroMed Inc.
Solola Taofiq
Wilmer Cutler Pickering Hale and Dorr LLP
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