Metalloproteinase inhibitors for wound healing

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

10032376

ABSTRACT:
The invention provides inhibitors of matrix metalloproteinases that are useful for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions and wound dressings that facilitate healing.

REFERENCES:
patent: 5270447 (1993-12-01), Liotta et al.
patent: 5280106 (1994-01-01), Liotta et al.
patent: 5372809 (1994-12-01), Liotta et al.
patent: 5585356 (1996-12-01), Liotta et al.
patent: 5698671 (1997-12-01), Stetler-Stevenson et al.
patent: 5770691 (1998-06-01), Fields et al.
patent: 5811252 (1998-09-01), Verheijen
patent: 5869277 (1999-02-01), Stetler-Stevenson et al.
patent: 6043087 (2000-03-01), Bini et al.
patent: 6127139 (2000-10-01), Te Koppele et al.
patent: 6184022 (2001-02-01), Seiki et al.
patent: 6191225 (2001-02-01), Barkac et al.
patent: 6204043 (2001-03-01), Shapiro
patent: H1973 (2001-07-01), Hu
patent: 6274703 (2001-08-01), Goldberg
patent: 6399371 (2002-06-01), Falduto et al.
patent: 6482802 (2002-11-01), Hu et al.
patent: 6753310 (2004-06-01), Oku et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 6906036 (2005-06-01), Quirk et al.
patent: 2001/0016333 (2001-08-01), Seiki et al.
patent: 2001/0031478 (2001-10-01), Bronstein et al.
patent: 2002/0099004 (2002-07-01), Lund et al.
patent: 2003/0012794 (2003-01-01), Srivastava et al.
patent: 2003/0096757 (2003-05-01), Quirk et al.
patent: 2003/0166567 (2003-09-01), Quirk et al.
patent: 2003/0199440 (2003-10-01), Dack et al.
patent: 2004/0010001 (2004-01-01), Au et al.
patent: 2004/0259802 (2004-12-01), Yang et al.
patent: 2005/0239710 (2005-10-01), Quirk et al.
patent: 06213888 (1994-05-01), None
patent: 06300757 (1994-10-01), None
patent: 07159402 (1995-06-01), None
patent: 07330795 (1995-12-01), None
patent: 08134098 (1996-05-01), None
patent: 08136548 (1996-05-01), None
patent: 08217800 (1996-08-01), None
patent: 09023889 (1997-01-01), None
patent: 09084589 (1997-03-01), None
patent: 09087299 (1997-03-01), None
patent: 09136841 (1997-05-01), None
patent: 09206099 (1997-08-01), None
patent: 09249700 (1997-09-01), None
patent: 10210982 (1998-08-01), None
patent: 10287700 (1998-10-01), None
patent: 10313896 (1998-12-01), None
patent: 2000270874 (2000-10-01), None
patent: 2001011093 (2001-01-01), None
patent: 2001072589 (2001-03-01), None
patent: WO 90/10228 (1990-09-01), None
patent: WO 94/10208 (1994-05-01), None
patent: WO-95/02045 (1995-01-01), None
patent: WO 96/18725 (1996-06-01), None
patent: WO 97/25437 (1997-07-01), None
patent: WO 98/04287 (1998-02-01), None
patent: WO 98/12309 (1998-03-01), None
patent: WO 98/31818 (1998-07-01), None
patent: WO-9834641 (1998-08-01), None
patent: WO-9834641 (1998-08-01), None
patent: WO 98/40475 (1998-09-01), None
patent: WO 98/42865 (1998-10-01), None
patent: WO 99/05261 (1999-02-01), None
patent: WO-99/31969 (1999-07-01), None
patent: WO-9958126 (1999-11-01), None
patent: WO-9958126 (1999-11-01), None
patent: WO 99/65519 (1999-12-01), None
patent: WO 00/20860 (2000-04-01), None
patent: WO-00/53219 (2000-09-01), None
patent: WO 00/63227 (2000-10-01), None
patent: WO-0074634 (2000-12-01), None
patent: WO-0074634 (2000-12-01), None
patent: WO 01/10437 (2001-02-01), None
patent: WO-01/13937 (2001-03-01), None
patent: WO 01/38558 (2001-05-01), None
patent: WO-01/54723 (2001-08-01), None
patent: WO 01/62206 (2001-08-01), None
patent: WO 01/62261 (2001-08-01), None
patent: WO-03018748 (2003-03-01), None
patent: WO-03018748 (2003-03-01), None
“PCT Search Report for International Application PCT US02/26319”, (Apr. 15, 2004),2 pages.
Berend, K. R., et al., “Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma”,Journal of Bone&Joint Surgery—American Volume. 80(1), (1999), 893-895.
Kerkela, E., et al., “Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation”,Bone, 29(5), (2001), 487-493.
Sakamoto, A., et al., “Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma”,Journal of Cancer Research&Clinical Oncology, 125(10), (1999), 541-548.
Soderstrom, M., et al., “Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas”,APMIS, 109(4), (2001), 305-315.
Ågren, Magnus S. ,“Matrix Metalloproteinases (MMPs) are Required for Re-epitheliazation..”,Arch Dermatol Res. (1999), 583-590.
Attie, Kenneth M., “Genetic Studies in Idiopathic Short Stature”,Current Opinion in Pediatrics, (2000), 400-404.
Azzam, H.S., et al., “Association of MMP-2 Activation Potential with Metastatic . . . ”,J Natl Cancer Inst, (1993), 1758-1764.
Becker, Joseph W., et al., “Stromelysin—1: Three-dimensional Structure of the Inhibited . . . ”,Protein Science, (1995), 1966-1976.
Bhide, V.M., et al., “Use of a Fluorogenic Septapeptide Matrix Metalloproteinase Assay . . . ”,J Periodontol, May 2000, 690-700.
Bickett, D.M., et al., “A High Throughput Fluorogenic Substrate for Interstitial Collagenase . . . ”,Anal Biochem, (1993), 58-64.
Bickett, D.M., et al., “A High Throughput Fluorogenic Substrate for Stromelysin (MMP-3)”,Ann N Y Acad Sci, (1994), 351-355.
Blaschke, Rüdiger J., et al., “SHOX: Growth Léri-Weill and Turner Syndromes”,TEM, vol. 11, No. 6, (2000), 227-230.
Bremer, C., et al., “In Vivo Molecular Target Assessment or Matrix Metaloproteinase . . . ”,Nat Med, (2001), 743-748.
Brown, P.D., et al. “Cellular Activation of the 72 kDa type IV Procollagenase / TIMP-2 . . . ”,Kidney Int, (1993), 163-170.
Brown, Rebeccah L., et al., “PDGF and TGF-a Act Synergistically to Improve Wound Healing . . . ”,Journal of Surgical Research, vol. 56, No. 6, (1994), 562-570.
Browner, Michelle F., et al., “Matrilysin-Inhibitor Complexes: Common Themes among Metalloproteases”,Biochemistry, vol. 34, (1995), 6602-6610.
Cabrele, Chiara, et al., “Y-receptor Affinity Modulation by the Design of Pancreatic . . . ”,Peptides, vol. 22, (2001), 365-378.
Calabrese, Edward J., “Cell Migration / Chemotaxis: Biphasic Dose Responses”,Critical Reviews in Toxicology, vol. 31, Issues 4 & 5, (2001), 615-624.
Calvin, Melissa, “Cutaneous Wound Repair”,Wounds: A Compendium of Clinical Research and Practice, vol. 10, No. 1, (1998), 12-32.
Chen, L.C., et al., “Disruption of the Cysteine-75 and Zinc Ion Coordination is Not Sufficient . . . ”,Biochemistry, (1993), 10289-10295.
Chin, Jason W., et al., “Concerted Evolution of Structureand Function in a Miniature Protein . . . ”,J. Am Chem Soc, vol. 123, No. 12, (2001), 2929-2930.
Chin, Jason W., et al., “Methodology for Optimizing Functional Miniature Proteins Based on Avian . . . ”,Bioorganic&Medicinal Chemistry Letters, vol. 1, (2001), 1501-1505.
Clark, Richard A.F., “Wound Repair”,The Molecular and Cellular Bilogy of Wound Repair, 2nd Ed., (1996), 3-50.
Colandrea, Teresa D., et al., “Epidermal Expression of Collagenase Delays Wound-Healing . . . ”,The Journal of Investigative Dermatology, vol. 111, No. 6, (1998), 1029-1033.
Duivenoorden, Wilhelmina C.M., et al., “Use of Tetracycline as an Inhibitor of Matrix Metalloproteinase . . . ”,Invasion Metastasis, (1997), 312-322.
Duncan, M.E., et al., “Human Matrix Metalloproteinase-9: Activation by Limited Trypsin”,Eur J Biochem, Nov. 15, 1998.
Farmer, W.H., et al., “A Continuous Fluorescent Assay for Measuring Protease Activity . . . ”,Anal Biochem. (

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Metalloproteinase inhibitors for wound healing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metalloproteinase inhibitors for wound healing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metalloproteinase inhibitors for wound healing will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3789295

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.