Synthetic compounds and compositions with enhanced cell binding

Details Synthetic compounds and compositions with enhanced cell binding Synthetic compounds and compositions with enhanced cell binding

2007-04-03

2007-04-03

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S015800, C514S016700, C514S017400

Reexamination Certificate

active

10927517

ABSTRACT:
Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction and for in vitro uses. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docking of collagen binding species (such as cell surface receptors for collagen and fibronectin) and have the amino acid residues -Ile-Ala-folded in a β-bend.

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