Surgery – Respiratory method or device – Ozone or ion generation
Patent
1979-12-11
1982-03-30
Michell, Robert W.
Surgery
Respiratory method or device
Ozone or ion generation
128395, 422 44, 128 1R, 128DIG3, A61M 103
Patent
active
043219195
ABSTRACT:
A method and system are disclosed for externally treating human blood, with the objective of reducing the functioning lymphocyte population in the blood system of a human subject. According to the method, blood is withdrawn from the subject and passed through an ultraviolet radiation field in the presence of from about 1 nanogram to 100 micrograms per ml of blood, of a dissolved psoralen capable of forming photoadducts with DNA, to thereby effect covalent bonding between the psoralen and the nucleic acid of the lymphocytes, thereby altering the said nucleic acid and inhibiting the metabolic processes of the lymphocytes; and thereupon returning the irradiated blood to the subject. The withdrawn blood may be formed into an extracorporeal stream and flowed through a treatment station whereat the irradiation is effected, as for example by exposure to UV energy in the wave length range of from about 3200 to 4000 Angstroms; and such flow process may be conducted on a continuous basis. If desired, at least portions of the treated blood may then be separated, as for example by a continuous centrifuge, before returning the remaining diverted blood to the subject.
REFERENCES:
patent: 1683877 (1928-09-01), Edblom et al.
patent: 3788319 (1974-01-01), Gillette
Bordin, Fand Baccichetti, Furocoumarin Photosensitive Effect on Virus-Producing Graffi Leukemia Cells, 1974.
Psoralen Photosensitization of LI210 Leukemia Cells . . . Carlasse, F. et al, 2, Naturforsch, 33c, 92-95, 1978.
Sunlight and Man, Chapt. 22, Fitzpatrick (ed), U. of Tokyo Press, 1974.
Leukocyte Research, Inc.
Michell Robert W.
Swisher Nancy A. B.
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