Real time detection of antigens

Details Real time detection of antigens Real time detection of antigens

2007-05-22

2007-05-22

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

C435S007100, C435S007920, C435S286500, C436S524000, C210S656000, C210S661000

Reexamination Certificate

active

10317853

ABSTRACT:
Antigens can be captured and detected from complex samples, such as food and environmental samples, in about 30 minutes using apparatus and methods that include flow of the samples through a module containing antibodies coupled to beads. The samples flow through the modified beads at about 0.2 to 1.2 liters/minute, which fluidizes the bead bed. The antigens are captured by the antibodies, and then detection of the captured antibodies is carried out with chemiluminescence, fluorescence, or spectrophotometric techniques.

REFERENCES:
patent: 1716321 (1929-06-01), Pearson
patent: 2798718 (1957-07-01), Gross
patent: 3002092 (1961-09-01), Cary
patent: 3025142 (1962-03-01), Williams
patent: 3492396 (1970-01-01), Dalton et al.
patent: 3600063 (1971-08-01), Bowen
patent: 3740552 (1973-06-01), Pressman
patent: 3947352 (1976-03-01), Cuatrecasas et al.
patent: 4059685 (1977-11-01), Johnson
patent: 4153675 (1979-05-01), Kleinerman
patent: 4157323 (1979-06-01), Yen et al.
patent: 4173392 (1979-11-01), Ekinaka et al.
patent: 4201831 (1980-05-01), Slusarczuk et al.
patent: 4217338 (1980-08-01), Quash
patent: 4225487 (1980-09-01), Cuatrecasas et al.
patent: 4268171 (1981-05-01), Sternberg
patent: 4314905 (1982-02-01), Etzel et al.
patent: 4347244 (1982-08-01), Mynard et al.
patent: 4348107 (1982-09-01), Leif
patent: 4352884 (1982-10-01), Nakashima et al.
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4454234 (1984-06-01), Czerlinski
patent: 4469787 (1984-09-01), Woods et al.
patent: 4478946 (1984-10-01), Van der Merwe et al.
patent: 4483807 (1984-11-01), Asano et al.
patent: 4495074 (1985-01-01), Hagiwara et al.
patent: 4505260 (1985-03-01), Metzger
patent: 4582809 (1986-04-01), Block et al.
patent: 4585623 (1986-04-01), Chandler
patent: 4652518 (1987-03-01), Makela et al.
patent: 4652533 (1987-03-01), Jolley
patent: 4668591 (1987-05-01), Minemura et al.
patent: 4678268 (1987-07-01), Russo et al.
patent: 4713347 (1987-12-01), Mitchell et al.
patent: 4714345 (1987-12-01), Schrader
patent: 4732811 (1988-03-01), Margel
patent: 4738773 (1988-04-01), Müller-Ruchholtz et al.
patent: 4775515 (1988-10-01), Cottingham
patent: 4780423 (1988-10-01), Bluestein et al.
patent: 4837305 (1989-06-01), Goodman et al.
patent: 4895650 (1990-01-01), Wang
patent: 4912051 (1990-03-01), Zaromb
patent: 4963498 (1990-10-01), Hillman et al.
patent: 5110624 (1992-05-01), Noble et al.
patent: 5110727 (1992-05-01), Oberhardt
patent: 5120643 (1992-06-01), Ching et al.
patent: 5147777 (1992-09-01), Sutton et al.
patent: 5183486 (1993-02-01), Gatten et al.
patent: 5183740 (1993-02-01), Ligler et al.
patent: 5192551 (1993-03-01), Willoughby, Jr. et al.
patent: 5216130 (1993-06-01), Line et al.
patent: 5225330 (1993-07-01), Ginsburg et al.
patent: 5235028 (1993-08-01), Barany et al.
patent: 5240602 (1993-08-01), Hammen
patent: 5240640 (1993-08-01), Siiman et al.
patent: 5292840 (1994-03-01), Heilmann et al.
patent: 5314830 (1994-05-01), Anderson et al.
patent: 5372783 (1994-12-01), Lackie
patent: 5395754 (1995-03-01), Lambotte et al.
patent: 5437983 (1995-08-01), Watts et al.
patent: 5466609 (1995-11-01), Siiman et al.
patent: 5501863 (1996-03-01), Rössling et al.
patent: 5512659 (1996-04-01), Ullman et al.
patent: 5552086 (1996-09-01), Siiman et al.
patent: 5554340 (1996-09-01), Lackie
patent: 5565365 (1996-10-01), Glass
patent: 5620858 (1997-04-01), Armstrong et al.
patent: 5627233 (1997-05-01), Hubbell et al.
patent: 5637576 (1997-06-01), Heerze et al.
patent: 5639620 (1997-06-01), Siiman et al.
patent: 5665561 (1997-09-01), Tuomanen et al.
patent: 5665582 (1997-09-01), Kausch et al.
patent: 5707877 (1998-01-01), Siiman et al.
patent: 5713943 (1998-02-01), Lindegren
patent: 5721109 (1998-02-01), Yano et al.
patent: 5776706 (1998-07-01), Siiman et al.
patent: 5843633 (1998-12-01), Yin et al.
patent: 5858534 (1999-01-01), Sucholeiki
patent: 5858802 (1999-01-01), Chai-Gao et al.
patent: 5928880 (1999-07-01), Wilding et al.
patent: 6120734 (2000-09-01), Lackie
patent: 6193953 (2001-02-01), Lohrmann et al.
patent: 6277257 (2001-08-01), Paul et al.
patent: 1 152 898 (1983-08-01), None
patent: 0 206 077 (1986-12-01), None
patent: 0 317 286 (1989-05-01), None
patent: 0 382 215 (1990-08-01), None
patent: 0 404 258 (1990-12-01), None
patent: 0 170 697 (1991-10-01), None
patent: 1 439 175 (1976-06-01), None
patent: 1507-421 (1987-05-01), None
patent: 1572-678 (1988-05-01), None
patent: 81/02529 (1981-09-01), None
patent: 87/01608 (1987-03-01), None
patent: 87/05003 (1987-08-01), None
patent: 90/07380 (1990-07-01), None
Manca et al., Antigenicity of HIV-derived T Helper determinants in the context of carrier recombinant proteins: Effect on T helper cell repertoire selection. European Journal of Immunology, (1996) vol. 26, No. 10, abstract only.
Blake et al., Imunomagnetic Detection ofBacillus stearothermophilusSpores in Food and Environmental Samples, Applied and Environmental Microbiology, May 1997, p. 1643-1646.
Forrest, “Development and Application of a Fully Automated Continuous Flow Radioimmunoassay System,” Ann. clin. Biochem., 14, 1-11, 1977.
Freytag et al., “A Highly Sensitive Affinity-Column-Mediated Immunometric Assay, as Exemplified by Digoxin,” Clin. Chem., 30/3, 417-420, 1984.
Freytag et al., “Affinity-Column-Mediated Immunoenzymometric Assays: Influence of Affinity-Column Ligand and Valency of Antibody-Enzyme Conjugates,” Clin. Chem., 30/9, 1494-1498, 1984.
Friguet et al., “Measurements of the True Affinity Constant in Solution of Antigen-Antibody Complexes by Enzyme-Linked Immunosorbent Assay,” Journal of Immunological Methods, 77, 305-319, 1985.
Glaser, “Antigen-Antibody Binding and Mass Transport by Convection and Diffusion to a Surface: A Two-Dimensional Computer Model of Binding and Dissociation Kinetics,” Analytical Biochemistry, 213, 152-161, 1993.
Gübitz et al., “Flow-injection immunoassays,” Analytica Chimica Acta, 283, 421-428, 1993.
Gunaratna et al., Noncompetitive Flow Injection Immunoassay for Hapten, α-(Difluoromethyl)ornithine, Anal. Chem., 65, 1152-1157, 1993.
Hudson, Jr.,Infrared System Engineering, Wiley-Interscience, 289 and 294-296, 1969.
Jolley et al., “Particle Concentration Fluorescence Immunoassay (PCFIA): a New, Rapid Immunoassay Technique with High Sensitivity,” Journal of Immunological Methods, 67, 21-35, 1984.
O'Shannessy, et al., “Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods,” Anal. Biochem., 212, 457-468, 1993.
Ordentlich et al., “Rhizosphere Colonization bySerratia Marcescensfor the Control ofSclerotium Rolfsil,” Soil. Biol. Biochem., 19, 747-751, 1987.
Plant et al., “Lipsome-Enhanced Flow Injection Immunoanalysis,” Biotechnology, 6, 266-269, 1988.
Pollema et al., “Sequential Injection Immunoassay Utilizing Immunomagnetic Beads,” Analytical Chemistry, 64, 1356-1361, 1992.
Pollema et al., “Flow Injection Renewable Surface Immunoassay: A New Approach to Immunoanalysis with Fluorescence Detection,” Anal. Chem., 66, 1825-1831, 1994.
Sambucetti et al., “Process for Purification of Magnetic Ink,” IBM Technical Disclosure Bulletin, 18, 593-595, 1975.
Sato et al., “A Novel Method for Isolating Specific Endocytic Vesicles Using Very Fine Ferrite Particles Coated with Biological Ligands and the High-Gradient Magnetic Separation Technique,” J. Biochem., 100, 1481-1492, 1986.
Smith, Modern Optical Engineering: The Design of Optical Systems, McGraw-Hill, Inc. (pubs), 1966.
Blake, M.R. et al., “Immunomagnetic Detection ofBacillus stearothermophilusSpores in Food and Environmental Samples,” Applied and Environmental Microbiology, 63 (5), pp. 1643-1646, May 1997.
“Food Safety: Magnetic Beads Detect Spores,” Food Ingredient News, 5 (6), Jun. 1997.
Manca, F. et al., “Antigenicity of HIV-derived T helper determinants in the context of c

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