Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Reexamination Certificate
2007-07-17
2007-07-17
Ghali, Isis (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
C424S448000, C424S443000, C424S445000, C424S447000, C514S944000, C514S946000, C514S947000
Reexamination Certificate
active
10631539
ABSTRACT:
A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered nonsteroidal anti-inflammatory drugs (NSAIDs). The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the NSAID through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with an NSAID are provided as well.
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Aungst et al. (1990), “Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines,”Pharmaceutical Research 7(7):712-718.
Hsu Tsung-Min
Luo Eric C.
Dermatrends, Inc.
Fredrikson & Byron , P.A.
Ghali Isis
LandOfFree
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