Isolation and expression of a disabled protein gene mDab1...

Details Isolation and expression of a disabled protein gene mDab1... Isolation and expression of a disabled protein gene mDab1...

2007-07-31

2007-07-31

Bragdon, Kathleen Kerr (Department: 1656)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000, C435S410000, C435S252300, C435S254200, C435S023000

Reexamination Certificate

active

09486293

ABSTRACT:
A mammalian homology ofDrosophilaDisabled protein has been identified and cloned. In particular, the murine homolog designated mDab1 has been cloned and expressed. mDab1, when tyrosine phosphorylated, binds to the SH2 domain of Src, Abl and Fyn. Antibodies specific for mDab1 are provided as are methods for the screening of agents for their ability to modulate mDab1 activity. Methods for diagnosing Disabled protein associated disease are also provided.

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