Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-31
2007-07-31
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
10532196
ABSTRACT:
Disclosed is a pharmaceutical composition for preventing and treating addiction to morphine or preventing and inhibiting the development of tolerance to the analgesic effects of morphine, containing berberine as an effective ingredient, wherein the berberine has an inhibitory effect versus psychological dependence on abused drugs such as morphine and the increase of spontaneous locomotor activity upon administration of the drugs, The pharmaceutical composition and aCoptis japonicaplant extract of the present invention, which contain berberine, are highly effective in inhibiting the aforementioned symptoms of morphine addiction, and are thus useful for prevention and treatment of addiction to abused drugs such as morphine. In addition, the pharmaceutical composition additionally containing a pharmaceutical acceptable carrier can be applied to prevent and inhibit morphine tolerance caused by repeated administration of morphine, while not affecting the analgesic effects of morphine upon a single administration.
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A. Brissemoret, ‘Note sur Less Plantes Anti-Opium’, Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales, 1925, vol. 93, 1341-1343 p. 1342, paragraph 6-7; claim 1-4.
Anna Capasso, Nunziatina de Tommasi, Luca Rastrelli, Francesco de Simone, ‘New Protopine Alkaloids from Aristolochia constrieta Reduce Morphine Withdrawl in vitro’, Phytother. Res., 2000, vol. 14, 653-655 the whole document ;claim 1-4.
Ge Xiaoqun, Zhang Hongquan, Zhou Hauzhu, Xu Shengxin, Bian Chunfu, ‘Experimental Study of Tetrahyrdoprotoberberines Inhibiting Morphine Withdrawl Syndromes’, Chin. J. Drug Depend., 1999, vol. 8, No. 3, 195-198 the whole document, claim 1-4.
Jin Gz, Wang Xl, Shi Wx, ‘Tetrahydroprotoberberine-a New Chemical Type of Antagonist of Dopamine Receptors’, Sie Sin B, 1986, vol. 29+ No. 5, 527-534 the whole document; claim 1-4.
Jang Choon-Gon
Lee Seok-Yong
Chu Yong
Saeed Kamal A.
Sungkyunkwan University
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