Acyl deoxyribonucleoside derivatives and uses thereof

Details Acyl deoxyribonucleoside derivatives and uses thereof Acyl deoxyribonucleoside derivatives and uses thereof

2007-01-30

2007-01-30

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S046000, C514S047000, C514S048000, C514S049000, C514S050000, C514S051000, C514S917000

Reexamination Certificate

active

09494243

ABSTRACT:
The invention relates to compositions comprising acyl derivatives of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.

REFERENCES:
patent: 3585188 (1971-06-01), Marumoto et al.
patent: 3856776 (1974-12-01), Cehovic
patent: 3860706 (1975-01-01), Ikeda
patent: 3894000 (1975-07-01), Wechter et al.
patent: 3975367 (1976-08-01), Gish et al.
patent: 3991045 (1976-11-01), Ishida
patent: 4048432 (1977-09-01), Baker
patent: 4208406 (1980-06-01), Lapinet
patent: 4560678 (1985-12-01), Ranson
patent: 4657896 (1987-04-01), Yano
patent: 4675189 (1987-06-01), Kent et al.
patent: 4757139 (1988-07-01), Kawaguchi
patent: 4758553 (1988-07-01), Ogoshi
patent: 4868162 (1989-09-01), Kawaguchi
patent: 5246708 (1993-09-01), von Borstel et al.
patent: 6020322 (2000-02-01), von Borstel et al.
patent: 1941942 (1971-03-01), None
patent: 3319282 (1983-11-01), None
patent: 0222192 (1987-05-01), None
patent: 835941 (1964-11-01), None
patent: AL 2556727 (1985-06-01), None
patent: 2152814 (1984-12-01), None
patent: 2023085 (1977-02-01), None
patent: 57-091995 (1982-06-01), None
patent: 5849315 (1983-03-01), None
patent: 58-167598 (1983-10-01), None
patent: 60-0028929 (1985-02-01), None
patent: 60-064907 (1985-04-01), None
Martin et al, J. of Pharmaceutical Sciences, vol. 76, No. 2, pp. 180-184 (1987).
Kanazir et al, Bull. Inst. Nuc. Sci. “Boris, Kidrich” 9:145-153 (1959).
Beltz et al, Bioch. Biophys. Acta, vol. 297, pp. 258-267 (1973).
Hunting, D.J.. et al, Carcinogenesis, vol. 6, pp. 1525-1528 (1985).
Golba, et al, Int. J. Rad. Biol. 13:261-268 (1967).
Goh et al, Proc. Soc. Exp. Biol. Med. 145:938-943 (1974).
Horikawa et al, Exp. Cell Res. 34:198-200 (1964).
Pantic et al, Nature 193:993-994 (1962).
Paoletti et al, Rev. Francais, Etudes Clin. et Bio. 9:950-955 (1964).
Petrovic et al, Int. J. Radiat. Biol. 18:243-258 (1970).
Petrovic et al, Studia Biophysica 43:13-18 (1974).
Petrovic et al, Int. J. Radiat. Res. 11:609-611 (1967).
Savkovic et al, Nature 203:1297-1298 (1964).
Savkovic et al, Nature 211:1179-1180 (1966).
Savkovic et al, Int. J. Rad. Biol. 9:361-368 (1965).
Smets et al, Int. J. Rad. Biol. 13:269-273 (1967).
Soska et al, Folia Biologica 5:190-198 (1959).
Sugahara et al, Brookhaven Symposia in Biology, 284-302 (1967).
Wagner, Int. J. Rad. Biol. 12:101-112 (1967).
Wilczok et al, Int. J. Rad. Biol. 9:201-211 (1965).
Goyanes-Villaescusa et al, Lancet 2:575-576 (1973).
Dumont, Ann. Surg. 150:799-807 (1959).
Nicolau et al, Der Hautarzt, 17:512-515 (1966).
Marshak et al, Proc. Soc. Exp. Bid. Med. 58:62-63 (1945).
Newman et al, Am. J. Physiol. 164:251-253 (1951).
Casida et al, Biochemical Pharmacology 15:627-644 (1966).
Rosowsky et al, Cancer Treatment Reports 65:93-99 (Jan./Feb. 1981).
Ensminger et al, Biochemical Pharmacology 28:1541-1545 (Oct. 1978).
Szoka, Jr. et al, (1978), Proc. Natl. Acad. Sci., vol. 75, No. 9, pp. 4194-4198.
Wechter et al, “Ara-Cytidine Acylates. Use of . . . Relationship Correlation 1,2,”, Journal of Med. Chem. 18, No. 4 (1975), pp. 339-344.
Wechter et al, Nucleic Acids. 16. Orally . . . Cybidine 1,2,,, Journal of Medicinal Chemistry, 19, No. 8 (1976), pp. 1013-1016.
DeLapp et al, “Important of Pyrimidine . . . In Skin”, J. Investigative Dermatol 66:306-312 (1976).
R.D. Snyder, “The Role of Deoxynucleoside . . . By Hydroxyurea”, Mutation Research, 131 (184), pp. 163-172.
Okabe et al, “A Method for Experimental, . . . Ulcers in Rats”, Digestive Diseases, vol. 16, No. 3 (Mar. 1971), pp. 277-283.
1988 Physician's Desk Reference, pp. 1551-1552.
Braun et al, Proc. Soc. Exptl. Biol. Med. 119:701-707 (1965).
Chemical Abstracts, vol. 74, No. 112368K, Rajabalee, Agnew. Chem. Int. Ed., Engl. 10(1):75 (1971).
Patent Abstracts of Japan, vol. 9, No. 160 (C-289)[1883], Jun. 4, 1985 (JP-A-60 034913) (Seikagaku Kogyo K.K.) Feb. 22, 1985).
Patent Abstracts of Japan, vol. 6, No. 266 (C-142)[1144], Dec. 25, 1982 (JP-A-57 156418 (Sumitomo Kagaku K.K.) Sep. 27, 1982).
Hackhs Chemical Dictionary 3rd ed. Julius Grant, ed. pp. 44, 45, 332, 333.
Ensminger et al, the Chemical Abstracts, 92: 87921x (1980).
Narang et al, the Chemical Abstracts, 83:147700a (1975).
Adamiak et al, the Chemical Abstracts, 106: 156803g (1987).
Pfleiderer, the Chemical Abstracts, 107: 218016j (1987).
Nair et al, the Chemical Abstracts, 101: 192832z (1984).
Ishido et al, the Chemical Abstracts, 92: 59149h (1980).
Fridovich, Annu. Rev. Biochem., 44:147-159 (1975).
BIOCHEMISTRY, vol. 13, No. 3, Jan. 29, 1974, pp. 553-559; M.J. Robins et al: ″3″-0-aminoacyl-2″-deoxyadenosines and 2″-0-aminoacyl-3″-deoxyadenosines related to charged transfer ribonucleic acid termini.
BIOCHEMISTRY, vol. 14, No. 14, Jul. 15, 1974, pp. 3144-3151; S.P. Dutta et al: Synthesis and properties of the naturally occurring N-[(9-beta-D-ribofuranosylpurin-6-yl)-N-methylcarbamoyl]-L-threonine (mt6A) and other related synthetic analogs.
BIOCHEMISTRY, vol. 20, No. 1, Jan. 6, 1981, pp. 8-15, American Chemical Society; A. Bhuta et al: “Stereochemical control of ribosomal peptidyltransferase reaction. Role of amino acid side-chain orientation of acceptor substrate”.
BIOCHEMISTRY, vol. 20, No. 12, Jun. 9, 1981, pp. 3480-3485, American Chemical Society; K. Quiggle et al: “Donor Site of Ribosomal Peptidyltransferase: Investigation of Substrate specificity using 2″(3″)-0-(N-acylaminoacyl)dinucleoside phosphates as models of the 3″terminus of N-acylaminoacyl transfer ribonucleic acid”.
Journal of American Chemical Society, vol. 104, No. 2, 1982, pp. 544-547, American Chemical Society; G. Buchi et al: “Photochemical epoxidation of aflatoxin B1 and sterigmatocystin: Synthesis of Guanine-Containing adducts”.
Pure and Applied Chemistry, vol. 52, No. 12, 1980, pp. 2705-2715, IUPAC GB; T. Matsuura et al: “Organic Chemical Approach to Photo-Cross-Links of Nucleic Acids to Proteins”.
Akman et al, Cancer Treatment Reports, 69(7-8), 851-857 (1985).
Derwent Abstract No. 91-212578 of Japanese Publication JO 3135918 (Ajinomoto) (1991).

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