Cyclic hemiacetal derivative and use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S475000

Reexamination Certificate

active

10507831

ABSTRACT:
A compound represented by the following formula (I)wherein R1is a lower alkyl group, R2is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or 1, which has a calpain inhibitory activity, is provided.

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“Inactivation of Calpain by Peptidyl Fluoromethyl Ketones”, J. Med. Chem., vol. 35, pp. 216-220, (1992).
“Isosterism and Molecular Modification in Drug Design”, C.W. Thornber, Imperial Chemical Industries Limited, Chem. Soc. Reviews, 8(4), pp. 563-580, (1979).
“Calpain inhibition: an overview of its therapeutic potential”, Trends in Pharmacological Sciences, vol. 15, pp. 412-419, (1994).
“Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal”, Curr. Eye Research, vol. 10, pp. 657-666, (1991).

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