Substituted glutaric acid lactones in the treatment of hyperlipi

Details Substituted glutaric acid lactones in the treatment of hyperlipi Substituted glutaric acid lactones in the treatment of hyperlipi

1985-03-11

1986-11-11

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549292, A61K 31365, C07D30930

Patent

active

046223380

ABSTRACT:
Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.

REFERENCES:
Houben-Weyl, Methoden der Organischen Chemie, vol. VI/2 (1963), pp. 778-780, 784-785.

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