Aroyl substituted dihydro-1,4-thiazines

Details Aroyl substituted dihydro-1,4-thiazines Aroyl substituted dihydro-1,4-thiazines

1984-06-29

1986-11-11

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 582, 544 584, C07D27910, A61K 3154

Patent

active

046223223

ABSTRACT:
Compounds of the formula ##STR1## wherein Ar is pyridyl or phenyl substituted by halogen, halo-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, or carboxy-C.sub.1 -C.sub.4 -alkyl, n is zero, one or two, R.sub.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl, heterocyclyl-C.sub.2 -C.sub.4 -alkyl, amino-C.sub.2 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylamino-C.sub.2 -C.sub.4 -alkyl, di-C.sub.1 -C.sub.4 -alkylamino-C.sub.2 -C.sub.4 -alkylor C.sub.1 -C.sub.4 -alkanoyl, and R.sub.2 is hydrogen, carboxy-C.sub.1 -C.sub.4 -alkyl, or C.sub.1 -C.sub.4 -alkoxy-carbonyl-C.sub.1 -C.sub.4 -alkyl are disclosed as well as their preparation, pharmaceutical compositions containing the same and the use thereof as antirheumatic agents.

REFERENCES:
patent: 3452001 (1969-06-01), Alt et al.
patent: 3835149 (1974-09-01), Renfroe
patent: 4427676 (1984-01-01), White et al.
patent: 4539320 (1985-09-01), Lang et al.
Hojo et al, 4-Alkyl-2H-1,4-Thiazin-3-Ones Synthesis 1982, 312-312.
Satzinger, Liebigs Ann. Chem. 1978, 473 (e.g. p. 488).
Alexander et al, J. Chem. Soc. Perkin Trans. I, 1974, 2092, 3,4-Dihydro-2H-1,4-Thiazines.
Renfroe, et al, Abstracts of 16th National Medicinal Chemistry Symposium, 1978 pp. 127-132.
Mikaiyama et al, Tetrahedron Letters, 1967, 3439.
Derwent Abstract 95085/E45 of French Patent No. 2509 303 (1/14/83).

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