Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-01-06
1986-11-11
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
548131, 540498, A61K 3155, C07D48704
Patent
active
046223207
ABSTRACT:
The application discloses novel benzodiazepine agonist compounds, namely, 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl-6-oxo-7-halo-4 H-imidazo [1,5-a][1,4]benzodiazepines, pharmaceutical compositions thereof, and a method of ameliorating central nervous system ailments therewith, especially convulsions and anxiolytic states. A novel intermediate and process for their production are also disclosed.
REFERENCES:
patent: 4316839 (1982-02-01), Gerecke et al.
patent: 4435403 (1984-03-01), Braestrup et al.
patent: 4507313 (1985-03-01), Braestrup et al.
Squires, Braestrup, "Benzodiazepine Receptors in Rat Brain", Nature, 266, (1977) pp. 732-734.
Litchfield, et al., "A Simplified Method of Evaluating Dose-Effect Experiments", Journal of Pharmacology and Experimental Therapeutics (1949) pp. 99-113.
Hartman, et al., "A Novel 1,3-Thiazole Synthesis via Alpha-Metallated Isocyanides and Thiono Esters", Synthesis (1976) pp. 681-682.
Chang, et al., "Benzodiazepine Receptors: Labeling in Intact Animals with [.sup.3 H] Flunitrazepam", Europe. J. Pharmacol., 48 (1978) pp. 213-218.
Engelstoft Mogens
Hansen John B.
Jensen Leif H.
Watjen Frank
AS Ferrosan
Bond Robert T.
Hueschen Gordon W.
LandOfFree
Oxadiazolylimidazobenzodiazepine, compositions, and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxadiazolylimidazobenzodiazepine, compositions, and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxadiazolylimidazobenzodiazepine, compositions, and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-377338