Method and composition for treating periodontal disease

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S029000, C514S035000, C514S036000, C514S253080, C514S573000

Reexamination Certificate

active

10635144

ABSTRACT:
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramicin, ciprofloxacin, clindamycin, clarithromycin, azithromycin and metronidazole. Preferred antibiotics are doxycycline and ciprofloxacin. More preferably, the antibiotic is doxycycline. In its second aspect, the present invention is directed to a method for treating periodontal disease in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. Typically, the mammalian patient is a human.

REFERENCES:
patent: 3965143 (1976-06-01), Collins et al.
patent: 4001286 (1977-01-01), Bundy
patent: 4009282 (1977-02-01), Voorhees
patent: 4025645 (1977-05-01), Jelenko, III
patent: 4113882 (1978-09-01), Okazaki et al.
patent: 4132738 (1979-01-01), Kluender et al.
patent: 4181725 (1980-01-01), Voorhees et al.
patent: 4185100 (1980-01-01), Rovee et al.
patent: 4201788 (1980-05-01), Voorhees et al.
patent: 4254145 (1981-03-01), Birnbaum
patent: 4282216 (1981-08-01), Rovee et al.
patent: 4353896 (1982-10-01), Levy
patent: 4360518 (1982-11-01), Rovee et al.
patent: 4459310 (1984-07-01), Dajani
patent: 4473565 (1984-09-01), Rovee et al.
patent: 4515810 (1985-05-01), Chow et al.
patent: 4707495 (1987-11-01), Rosenthale et al.
patent: 4764377 (1988-08-01), Goodson
patent: 4840968 (1989-06-01), Ohnishi
patent: 4889845 (1989-12-01), Ritter et al.
patent: 4919939 (1990-04-01), Baker
patent: 4925873 (1990-05-01), Friedhoff et al.
patent: 5015481 (1991-05-01), Franz et al.
patent: 5145686 (1992-09-01), Horrobin et al.
patent: 5167952 (1992-12-01), McHugh
patent: 5310759 (1994-05-01), Bockman
patent: 5324746 (1994-06-01), McKee et al.
patent: 5510384 (1996-04-01), McKee et al.
patent: 5994399 (1999-11-01), McKee et al.
patent: WO 91 16895 (1991-11-01), None
patent: WO 92 21350 (1992-12-01), None
The Merck Index, Thirteenth Edition, 2001-2005.
Lie et al J. Periodontal. 1998, 69, 819-827.
Eickholz et ak J. Clin. Periodontol. Feb. 2002, 29, 108-117.
Yang, Chinese Dental Journal, vol. 8, No. 2, 1989, pp. 44-57.
Miller et al., BONE, vol. 14, No. 2, 1993, pp. 143-151.
Chao, Acta Anat., vol. 132, No. 4, 1988, pp. 304-309.
Levi et al., The Lancet, vol. 336, 1990, POG106, pp. 840-843.
Northway et al., CANCER, vol. 62, No. 9, 1988, pp. 1962-1969.
Lanas et al., J. Clin. Gastroenterol., vol. 13, No. 6, 1991, pp. 622-627.
Garris et al., Clin. Pharm., vol. 8, No. 9, 1989, pp. 627-644.
Rocha et al. Crit. Rev. Immunology, vol. 12, No. 3-4, 1992, pp. 81-100.
Lanza, Scand J. Gastroenterol., vol. 24, No. Suppl. 163, 1989, pp. 36-43.
Chem. Abstracts No. 164424, issued Nov. 5, 1984.
Biol. Abstracts No. 1101, issued Jul. 1, 1989.
“Periodontal Regeneration”, Academy Report, American Academy of Periodontology, J. Periodontal, 2005:1601-1622.
Hellden et al., “The Effect Of Tetracycline And/Or Scaling On Human Periodontal Disease”, Journal of Clinical Periodontology: 1979: 6: 222-230.
Bonito et al., “Impact Of Local Adjuncts To Scaling And Root Planing In Periodontal Disease Therapy: A Systematic Review,” J. Periodontal, vol. 76, No. 8, 1227-1236, Aug. 2005.
Drisko, “Nonsurgical Periodontal Therapy,” Periodontology 2000, vol. 25, 2001, 77-88.
Hanes et al., “Local Anti-Infective Therapy : Pharmacological Agents. A Systematic Review,” Ann. Peridontol., vol. 8, No. 1, 79-98, Dec. 2003.
Hill et al., “Four Types Of Periodontal Treatment Compared Over Two Years,” J. Periodontol, vol. 52, No. 11, 655-662, Nov. 1981.
Preshaw et al., “Subantimicrobial Dose Doxycycline As Adjunctive Treatment For Periodontitis,” J. Clin. Periodontol 2004 ; 31: 697-707.
Ramfjord et al, “Results Following Three Modalities Of Periodontal Therapy,” J. Periodontol, vol. 46, No. 9, pp. 522-526, Sep. 1975.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and composition for treating periodontal disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and composition for treating periodontal disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for treating periodontal disease will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3769466

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.