Process for producing tolterodine

Details Process for producing tolterodine Process for producing tolterodine

2007-09-11

2007-09-11

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S315000

Reexamination Certificate

active

11421192

ABSTRACT:
The present invention provides a process for producing tolterodine of the formula (1) or its salt, which comprises a step reacting a compound of the formula (2) with a base to obtain a reaction product; a step reacting the reaction product with a compound of the formula (3) to obtain a compound of the formula (4); and a step eliminating the protective group from the compound of the formula (4), and also provides a process for producing the compound of the formula (3).

REFERENCES:
patent: 5382600 (1995-01-01), Jönsson et al.
patent: 5922914 (1999-07-01), Gage et al.
patent: 6822119 (2004-11-01), Kumar et al.
Chen, G., et al., “Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of (R)-Tolterodine”, Org. Lett., vol. 7, No. 11, pp. 2285-2288 (2005).
Kennedy-Smith, J. J., et al., “Rhenium-Catalyzed Aromatic Propargylation”, Org. Lett., vol. 6, No. 8, pp. 1325-1327 (2004).
Srinivas, K., et al., “An Improved, Scalable, and Impurity-Free Process for Tolterodine Tartrate”, Org. Proc. Res. & Develop., vol. 9, No. 3, pp. 314-318 (2005).
Botteghi, C., et al., “A New Efficient Route to Tolterodine”, Org. Proc. Res. & Develop., vol. 6, pp. 3719-383 (2002).
Andersson, P. G., et al., “Asymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinones”, J. Org. Chem., vol. 63, pp. 8067-8070 (1998).

Affiliated with

Also associated with

Rating

Process for producing tolterodine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing tolterodine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing tolterodine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3768581