Estrogen receptor modulators

Details Estrogen receptor modulators Estrogen receptor modulators

2007-07-03

2007-07-03

Foley, Shanon (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000, C435S069100

Reexamination Certificate

active

10108992

ABSTRACT:
The present invention relates to an estrogen receptor co-regulator and to antibodies specific therefor. The invention further relates to methods of screening test compounds for their suitability as estrogen receptor modulators and to methods of using same in disease treatment.

REFERENCES:
patent: 6020164 (2000-02-01), Bandman et al.
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Boehringer Mannheim Biochemicals, 1994 Catalog, p. 93.
Database NCBI Online (Bethesda, MD, USA) Entrez Nucleotide, Accession No. AL009266, Jan. 25, 1999—see attached Swiss-Prot 043251.
Norris et al, “A Negative Coregulator for the Human ER”, Mol. Endocrinol. 16(3):459-468 (2002).
Robyr et al, “Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks”, Mol. Endocrinol. 14(3):329-347 (2000).
Underwood et al, “Homologues of theCaenorhabditis elegansFox-1 Protein Are Neuronal Splicing Regulators in Mammals”, Molecular and Cellular Biology 25(22):10005-10016 (2005).
Li et al, “Cell type and culture condition-dependent alternative splicing in human breast cancer cells revealed by splicing-sensitive microarrays”, Cancer Res. 66(4):1990-1999 (2006)—Abstract.
Nakahata and Kawamoto, “Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities”, Nucleic Acids Research 33(7):2078-2089 (2005).

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