Methods for producing nateglinide crystals

Details Methods for producing nateglinide crystals Methods for producing nateglinide crystals

2007-04-24

2007-04-24

Oh, Taylor Victor (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S444000, C562S445000

Reexamination Certificate

active

10418105

ABSTRACT:
There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.

REFERENCES:
patent: 4816484 (1989-03-01), Toyoshima et al.
patent: 5463116 (1995-10-01), Sumikawa et al.
patent: 6844008 (2005-01-01), Yabuki et al.
patent: 2003/0021843 (2003-01-01), Makino et al.
patent: 2003/0073729 (2003-04-01), Kitahara et al.
patent: 2003/0229249 (2003-12-01), Sumikawa et al.
patent: 2003/0229429 (2003-12-01), Sumikawa et al.
patent: 2004/0014815 (2004-01-01), Ninomiya et al.
patent: 2004/0024219 (2004-02-01), Sumikawa et al.
patent: 2004/0030182 (2004-02-01), Takahashi et al.
patent: 0 196 222 (1986-10-01), None
patent: 0 526 171 (1993-02-01), None
patent: 07-017899 (1995-01-01), None
U.S. Appl. No. 11/319,177, filed Dec. 28, 2005, Sumikawa et al.

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