Polynucleotides encoding a human G-protein coupled receptor,...

Details Polynucleotides encoding a human G-protein coupled receptor,... Polynucleotides encoding a human G-protein coupled receptor,...

2007-04-03

2007-04-03

Li, Ruixiang (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S252300, C435S254110, C435S254200, C536S023500, C530S350000

Reexamination Certificate

active

10237813

ABSTRACT:
The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

REFERENCES:
patent: 6607879 (2003-08-01), Cocks et al.
patent: 6773895 (2004-08-01), Jung et al.
patent: 6806054 (2004-10-01), Lehmann-Bruinsma et al.
patent: WO0031261 (2000-06-01), None
patent: WO 01/77172 (2001-10-01), None
patent: WO0218938 (2002-03-01), None
patent: WO 02/028999 (2002-04-01), None
patent: WO02061087 (2002-08-01), None
patent: WO 02/068579 (2002-09-01), None
patent: WO 03/000928 (2003-01-01), None
patent: WO 03/031650 (2003-04-01), None
patent: WO03031650 (2003-04-01), None
patent: WO 03/054166 (2003-07-01), None
patent: WO 03/082314 (2003-10-01), None
patent: WO 03/106683 (2003-12-01), None
patent: WO 04/008141 (2004-01-01), None
patent: WO 04/040000 (2004-05-01), None
patent: WO 04/041170 (2004-05-01), None
patent: WO 04/041850 (2004-05-01), None
patent: WO 04/042346 (2004-05-01), None
patent: WO 04/078143 (2004-09-01), None
patent: WO 05/012875 (2005-02-01), None
patent: WO 05/024057 (2005-03-01), None
patent: WO 05/024058 (2005-03-01), None
patent: WO 05/047899 (2005-05-01), None
Database EMBL Accession No. AC018755, Dec. 23, 1999, “Homo sapiens chromosome 19, BAC BC330783 (CIT-HSPC—470E3), complete sequence.”, XP002302557.
NCBI Entrez Accession No. AC018755 (gi:9454515), Lamerdin, et al., Jul. 26, 2000.
NCBI Entrez Accession No. AAA58481 (gi:182667), Bao, et al., Dec. 31, 1994.
NCBI Entrez Accession No. CAA66322 (gi:172979), Alvarez, et al., Sep. 9, 2004.
NCBI Entrez Accession No. CAA66323 (gi:1732019), Alvarez, et al., Sep. 9, 2004.
NCBI Entrez Accession No. XP—031083 (gi:14754922), Jul. 16, 2001.
NCBI Entrez Accession No. XP—084009 (gi:18589712), May 8, 2002.
Alvarez, et al., “Molecular evolution of the N-formyl peptide and C5a receptors in non-human primates”, Immunogenetics, vol. 44, pp. 446-452 (1996).
Gronert, et al., “Identification of a Human Enterocyte Lipoxin A4Receptor That Is Regulated By Interleukin (IL)-13 and Interferon γ and inhibits Tumor Necrosis Factor α-induced IL-8 Release”, J. Exp. Med., vol. 187(8), pp. 1285-1294 (1998).
Murphy, et al., “A Structural Homologue of the N-Formyl Peptide Receptor”, J. Biol. Chem., vol. 267(11), pp. 7637-7643 (1992).
Takano, et al., “Aspirin-triggered 15-Epi-Lipoxin A4(LXA4) and LXA4Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors”, J. Exp. Med., vol. 185(9), pp. 1693-1704 (1997), XP-002141526.
Su, et al., “A Seven-transmembrane, G Protein-coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells”, J. Exp. Med., vol. 189 (2), pp. 395-402 (1999).
Le, et al., “Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1”, J. Neuroscience, vol. 21, (RC123), pp. 1-5 (2001).
Le, et al., Cutting Edge: The Neurotoxic Prion Peptide Fragment PrP106-126Is a Chemotactic Agonist for the G Protein-Coupled Receptor Formyl Peptide Receptor-Lime 11,2, J. Immunol, vol. 166, pp. 1448-1451 (2001).
Chiang, et al., “Activation of Lipoxin A4Receptors by Aspirin-triggered Lipoxins and Select Peptides Evokes Ligand-specific Responses in Inflammation”, J. Exp. Med., vol. 191 (7), pp. 1197-1207 (2000).
Yang, et al., “LL-37, the Neutrophil Granule- and Epithelial cell-derived Cathelicidin, Utilizes Formyl Peptide Receptor-like 1 (FPRL1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells”, J. Exp. Med., vol. 192 (7), pp. 1069-1074 (2000).
AbdAlla, S. et al., “AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration”, Nature, vol. 407, pp. 94-98 (2000).
Akbar, G.K. M. et al., “Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells*”, The Journal of Biological Chemistry, vol. 271, No. 31, pp. 18363-18367 (1996).
Altschul, S. et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”, Nucleic Acids Research, vol. 25, No. 17, pp. 3389-3402 (1997).
Alvarez, V. et al., “Molecular evolution of the N-formyl peptide and C5a receptors in non-human primates”, Immunogenetics, vol. 44, pp. 446-452 (1996).
Bae, Yoe-Sik et al., “Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing ofStaphylococcus aureusvia phospholipase D activation in human monocytes”, Journal of Leukocyte Biology, vol. 65, pp. 241-248 (1999).
Bae, Yoe-Sik et al., “Differential Activation of Formyl Peptide Receptor-Like 1 by Peptide Ligands1”, The Journal of Immunology, vol. 171, pp. 6807-6813 (2003).
Baldwin, Joyce, “Structure and function of receptors coupled to G proteins” Current Opinion in Cell Biology, vol. 6, pp. 180-190 (1994).
Bao, Lu et al., “Mapping of Genes for the Human C5a Receptor(C5AR), Human FMLP Receptor (FPR), and Two FMLP Receptor Homologue Orphan Receptors (FPRH1, FPRH2) to Chromosome 19”, Genomics, vol. 13, pp. 437-440 (1992).
Bateman, A. et al., “The Pfam Protein Families Database”, Nucleic Acids Research, vol. 28, No. 1, pp. 263-266 (2000).
Baud, V. et al., “EMR1, an Unusual Member in the Family of Hormone Receptors with Seven Transmembrane Segments”, Genomics, vol. 26, pp. 334-344 (1995).
Bolander, F. , “Molecular Endocrinology”, Academic Press, pp. 162-176 (1994).
Boulay, F. et al., “Synthesis and use of a Novel N-Formyl peptide derivative to Isolate a Human N-Formyl Peptide Receptor cDNA”, Biochem. Biophys, Research Comm., vol. 168(3) pp. 1103-1109 (1990).
Boulay, F. et al., “The HumanN-Formylpeptide Receptor. Characterization of Two cDNA Isolates and Evidence for a New Subfamily of G-protein-Coupled Receptors”, Biochemistry, vol. 29, pp. 11123-11133 (1990).
Christophe, T. et al., “Phagocyte Activation by Trp-Lys-Tyr-Met-Val-Met, Acting through FPRL1/LXA4R, is not affected by Lipoxin A4”, Scand. J. Immunol, vol. 56, pp. 470-476 (2002).
Cornfield, J. et al., “[3H]2-Phenylaminodenosine([3H]CV 1808) Labels a Novel Adenosine Receptor in Rat Brain”, The Journal of Pharmacology & Experimental Therapeutics, vol. 263(2), pp. 552-562 (1992).
Coughlin, Shaun R. et al., “Expanding horizons for receptors coupled to G proteins: diversity and disease”, Current Opinion in Cell Biology, vol. 6, pp. 191-197 (1994).
DeYang, B. et al., “LL-37, the Neutrophil Granule- and Epithelial cell-derived Cathelicidin, Utilizes Formyl Peptide Receptor-like 1 (FPRL1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells”, The Journal of Experimental Medicine, vol. 192(7), pp. 1069-1074 (2000).
Durstin, M. et al., “Differential expression of members of theN-Formylpeptide receptor gene cluster in human phagocytes”, Biochem, and Biophys. Comm., vol. 201(1), pp. 174-179 (1994).
Ernst, S. et al., “An Annexin 1 N-Terminal Peptide Activates Leukocytes by Triggering Different Members of the Formyl Peptide Receptor Family1”, The Journal of Immunology, vol. 172, pp. 769-7676 (2004).
Ernst, S. et al., “Agonist-induced trafficking of the low-affinity formyl peptide receptor FPRL1”, Cell. Mol. Life Sci., vol. 61, pp. 1684-1692 (2004).
Feng, Y, et al., “HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G

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