Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids

Details Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids

2007-01-23

2007-01-23

Lewis, Patrick (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S022100, C536S025310, C536S028100, C536S028400, C536S028530, C536S028540

Reexamination Certificate

active

10480013

ABSTRACT:
The present invention relates to calix[4]arene-nucleoside hybrids containing calix[4]arene moieties and calix[4]arene-oligonucleotide hybrids as a DNA hairpin structure mimics synthesized by using the calix[4]arene-nucleoside as a key building block. Calix[4]arene-nucleoside and calix[4]arene-oligonucleotide hybrids of the present invention can effectively recognize DNA or RNA through triplex formation by bonding between calix[4]arene containing cavity and biologically active substance.

REFERENCES:
Sidorov et al. Chem. Commun. (2000), pp. 2369-2370.
Rudkevich et al. J. Org. Chem. (1994), vol. 59, pp. 3683-3686.
Kim et al. Tetrahedron Letters (2002), vol. 43, pp. 6367-6371.
Zeng et al. Tetrahedron (2003), vol. 59, pp. 2539-2548.

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