Preparation of chiral cyclic amino acids and derivatives

Details Preparation of chiral cyclic amino acids and derivatives Preparation of chiral cyclic amino acids and derivatives

2007-05-08

2007-05-08

Page, Thurman (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S115000, C560S121000, C560S125000, C560S155000, C560S169000

Reexamination Certificate

active

10855103

ABSTRACT:
Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and enantioselectivity according to the reaction scheme:

REFERENCES:
patent: WO 99/59721 (1999-11-01), None
Dobbs et al. Angew. Chem. Int. Ed. 2000, 39, pp. 1992-1995.
Greene et al. “Protective Groups In Organic Synthesis” 2ndEdition, 1991, John Wiley & Sons Inc. pp. 229, 230, 318, 319, 327, 328, 335, 336.
Heller et al. Tetrahedron: Asymmetry, 2002, vol. 13, pp. 2735-2741.

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