Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Reexamination Certificate
2007-05-22
2007-05-22
Schwadron, Ronald B. (Department: 1644)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
C435S070200, C435S070400, C435S451000, C435S440000, C435S346000, C435S372000, C435S372100, C435S372200, C436S547000, C436S548000, C530S808000, C530S809000
Reexamination Certificate
active
09767578
ABSTRACT:
This invention provides: a heteromyeloma, other than B6B11, capable of producing a trioma when fused with a human lymphoid cell, wherein the trioma is capable of producing a monoclonal antibody-secreting tetroma when fused with a second, antibody-secreting human lymphoid cell; a trioma fusion partner which does not produce antibody, obtained by fusing a heteromyeloma which does not produce antibody with a human lymphoid cell; a monoclonal antibody-secreting tetroma, obtained by fusing a trioma which does not produce antibody with an antibody-secreting human lymphoid cell; a method of producing a monoclonal antibody that specifically recognizes an antigen associated with a condition; a method of identifying an antigen associated with a condition using the trioma fusion partner; a method of diagnosing a condition using the trioma fusion partner; a method for preventing a condition; and compositions and therapeutic compositions comprising monoclonal antibodies produced using the trioma fusion partner.
REFERENCES:
patent: 4574116 (1986-03-01), Kaplan et al.
patent: 4613576 (1986-09-01), Cote et al.
patent: 4618577 (1986-10-01), Handley et al.
patent: 4634664 (1987-01-01), Oestberg
patent: 4634666 (1987-01-01), Engleman et al.
patent: 4668629 (1987-05-01), Kaplan et al.
patent: 4689299 (1987-08-01), Insel et al.
patent: 4714681 (1987-12-01), Reading et al.
patent: 4720459 (1988-01-01), Winkelhake
patent: 4744982 (1988-05-01), Hunter et al.
patent: 4761377 (1988-08-01), Glassy et al.
patent: 4800155 (1989-01-01), Taniguchi et al.
patent: 4916072 (1990-04-01), Tsuji et al.
patent: 4950595 (1990-08-01), Masuho et al.
patent: 4954449 (1990-09-01), Hunter et al.
patent: 4997762 (1991-03-01), Hanna, Jr. et al.
patent: 5001065 (1991-03-01), Larrick et al.
patent: 5003046 (1991-03-01), Neville et al.
patent: 5006470 (1991-04-01), Yamaguchi et al.
patent: 5093261 (1992-03-01), Hagiwara et al.
patent: 5126259 (1992-06-01), Tada et al.
patent: 5196337 (1993-03-01), Ochi et al.
patent: 5215913 (1993-06-01), Posner
patent: 5252480 (1993-10-01), Yokota et al.
patent: 5298419 (1994-03-01), Masuho et al.
patent: 5426046 (1995-06-01), Kaplan et al.
patent: 5459060 (1995-10-01), Cotropia
patent: 5506132 (1996-04-01), Lake et al.
patent: 5576184 (1996-11-01), Better et al.
patent: 5652114 (1997-07-01), Chu et al.
patent: 6197582 (2001-03-01), Trakht
patent: 0137234 (1985-04-01), None
patent: 0695760 (1996-02-01), None
patent: 0799836 (1997-10-01), None
patent: 9427638 (1994-12-01), None
patent: WO 9947929 (1999-09-01), None
Gustafsson et al. Human Antibod, Hybridomas, 2:26-32, 1991.
Brodin T, Olsson L, Sjorgen H., “Closing of human hybridoma, myeloma and lymphoma cell lines using enriched human monocytes as feeder layer”J.Immunol.Meth. (1983) vol. 60, 1-7.
Goldman-Leikin, R.E., Salwen, H.R., Herst, C.V., Variakojis, D., Bian, M.L., Le Beau, M.M., Selvanayagan, P., Marder, R., Anderson, R., Weitzman, S., Rosen, S.T., “Characterization of a novel myeloma cell line MM-I”J.Lab.Clin.Med.(1989) vol. 113, 335-345.
Kozbor, D., Roder, J., “Requirements for the establishment of high titered human monoclonal antibodies against tetanus toxoid using the Epstein-Barr virus technique”J.Immunology(1981) vol. 127, 1275-1280.
Kozbor, D., Tripputi, P., Roder, J.C., Croce, C.M., “A human hybrid myeloma for production of human monoclonal antibodies”J.Immunology(1984) vol. 133, 3001.
Levy, R., Miller, R.A., “Tumor therapy with monoclonal antibodies”Federation Proceedings(1983) vol. 42, 2650-2656.
Nilsson, K., Ponten, J., “Classification and biological nature of established human hematopoetic cell lines”Int.J.Cancer(1975) vol. 15, 321-341).
Oestberg, L., Pursch, E., “Human×(Mouse×Human) Hybridomas Stably Producing Human Antibodies”Hybridoma(1983)vol. 2, 361-367.
Posner, M.R, Schlossman, S.F., Lazarus, H., “Novel approach to the construction of human “Myeloma Analogues” for the production of human monoclonal antibodies”Hybridoma(1983) vol. 2, 369-381.
Reading, C.L., “Theory and Methods for Immunization in Culture and Monoclonal Antibody Production”J.Immunol. Meth.(1982) vol. 53, 261-291.
Raison, R.L., Walker, K.Z., Halnan, C.R.E., Briscoe,D, Basten, A., “Loss of Secretion in Mouse-Human Hybrids Need Not Be Due to the Loss of a Structural Gene”J.Exp.Medicine(1982) vol. 156, 1380-1389.
Teng, N.N.H., Lam, K.S., Riera, F.C., Kalpan, H.S., “Construction and Testing of Mouse-Human Heteromyelomas for Human Monoclonal Antibody Production”Proc.Natl.Acad.Sci.(USA) (1983) vol. 80, 7308-7311.
Weiss, M.C., Green H., “Human-Mouse Hybrid Cell Lines Containing Partial Complements of Human Chromosomes and Functioning Human Genes”Proc.Natl.Acad.Sci.(USA) (1967) vol. 58, 1104-1111.
Carroll, W.L., Thielemans, K., Dilley, J. and Levy, R. (1986) Mouse×human heterohybridomas as fusion partners with human B cell tumors. J. Immunol. Methods 89: 61-72.
Kearney, J.F., Radbruch, A., Liesegang, B. and Rajewsky K. (1979) new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123: 1548-1550.
Cooper & Dunham LLP
Schwadron Ronald B.
The Trustees of Columbia University in the City of New York
White John P.
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