Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-31
2007-07-31
Wilson, James (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S472000, C562S430000, C562S450000
Reexamination Certificate
active
10559600
ABSTRACT:
Compounds of formula (I):wherein:Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring;X represents O, S, NR5or CR6R7;Y represents CHOH, CHSH, NOR8, CNR8or CNOR8;Z represents a bond, CR10R11, O, S, SO, SO2, NR10, OCR10R11, CR10R11O or Z,R4and Q together form an optionally substituted fused tricyclic group;R1, R1′, R3and R3′each independently represents H, C1-6alkyl or C1-4alkylaryl;R2represents CO2R8, CONR5OR9or NR5COR9;R4represents optionally substituted 5- or 6-membered aryl or heteroaryl;R5represents H or C1-3alkyl;R6and R7each independently represents H, C1-3alkyl or halo;R8represents H or C1-2alkyl;R9represents H or C1-3alkyl;R10and R11each independently represents H, C1-6alkyl or C1-4alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.
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Gaines Simon
Holmes Ian Peter
Watson Stephen Paul
Glaxo Group Limited
Hsu Grace C.
Kinzig Charles
Lao M. Louisa
McCarthy Mary E.
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