Peptides, derivates thereof, process for producing the same,...

Details Peptides, derivates thereof, process for producing the same,... Peptides, derivates thereof, process for producing the same,...

2007-09-11

2007-09-11

Campell, Bruce R. (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S260100

Reexamination Certificate

active

10632949

ABSTRACT:
Peptides having, as constitutive amino acids, (1) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; (2) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 3 valine residues, and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; or (3) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydodec-5-enoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof. The peptides have an antiviral activity. A strain capable of producing the above peptides and belonging to a new species of genusPseudomonas.

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Nielsen T.H. et al., “Viscosinamide, a new cyclic depsipeptide with surfactant and antifungal properties produced byPseudomonas fluorescensDR54,”Journal of Applied Mircobiology, Jul. 1999, vol. 87, No. 1, pp. 80-90.
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