Polymeric prodrugs of vancomycin

Details Polymeric prodrugs of vancomycin Polymeric prodrugs of vancomycin

2007-09-25

2007-09-25

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S322000

Reexamination Certificate

active

10705743

ABSTRACT:
Methods of preparing vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are preferably releasable, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related compounds. Vancomycin-polymer conjugates made by the methods and methods of treatment using the conjugates are also disclosed.

REFERENCES:
patent: 5681811 (1997-10-01), Ekwuribe
patent: 6395266 (2002-05-01), Martinez et al.
patent: WO97/04796 (1997-02-01), None
patent: WO 03/040211 (2003-05-01), None
Yuichi Ohya, et al., Synthesis and Cytotoxic Activity of Conjugates of Monomethoxy-Poly-(ethylene glycol) End-Capped with DoxorubicinviaEster, Amide, or Schiff's Base Bond, Journal of Bioactive and Compatible Polymers, vol. 10-Jan. 1995 pp. 51-66.

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