Peptides for regulation of urokinase (uPA) and tissue type...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S834000, C530S300000, C530S326000

Reexamination Certificate

active

10386777

ABSTRACT:
Compositions of the polypeptide SEQ ID NO:1, SEQ ID NO:2, anti-LRP antibodies, LRP antagonists, and/or one or more fibrinolytic agents are formulated for enhancing the fibrinolytic activity, reducing the side effects due to vasoactivity caused by the fibrinolytic agents, and/or prolonging the half lives of the fibrinolytic agents. The invention further relates to combination compositions and/or therapy regimens, comprising the polypeptide SEQ ID NO:1 and/or SEQ ID NO:2 and one or more currently used plasminogen activators.

REFERENCES:
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patent: 99/20295 (1999-04-01), None
Zhang et al. Regulation of Single Chain Urokinase Binding, Internalization, and Degradation by a Plasminogen Activator Inhibitor 1-Derived Peptide (1997) J. Biol. Chem. 272(43): 27053-27057.
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Herz, Joachim, et al., “LRP: a multifunctional scavenger and signaling receptor”, J. Clin. Invest., 2001, 108:779-784.
Haj-Yehia, A. et al., “Urokinase-derived peptides regulate vascular smooth muscle contraction in vitro and in vivo”, The FASEB Journal, 2000, 14:1411-1422.
Madison, E. L. et al., “Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1”, Proc. Natl. Acad. Sci. USA 87 (1990), 87:3530-3533.
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